摘要
The first microRNA was discovered in Caenorhabditis elegans in 1993, and since then, thousands of microRNAs have been identified from almost all eukaryotic organisms examined. MicroRNAs function in many biological events such as cell fate determination, metabolism, apoptosis, and carcinogenesis. So far, more than 250 microRNAs have been identified in C. elegans; however, functions for most of these microRNAs are still unknown. A small number of C. elegans microRNAs are associated with known physiological roles such as developmental timing, cell differentiation, stress response, and longevity. In this review, we summarize known roles of micro- RNAs in neuronal differentiation and function of C. elegans, and discuss interesting perspectives for future studies.
The first microRNA was discovered in Caenorhabditis elegans in 1993, and since then, thousands of microRNAs have been identified from almost all eukaryotic organisms examined. MicroRNAs function in many biological events such as cell fate determination, metabolism, apoptosis, and carcinogenesis. So far, more than 250 microRNAs have been identified in C. elegans; however, functions for most of these microRNAs are still unknown. A small number of C. elegans microRNAs are associated with known physiological roles such as developmental timing, cell differentiation, stress response, and longevity. In this review, we summarize known roles of micro- RNAs in neuronal differentiation and function of C. elegans, and discuss interesting perspectives for future studies.
基金
funded by the State Key Development Programme for Basic Research of China(No.2011CBA01103)
the National Natural Science Foundation of China(Nos.31071132,91232702,and 81171074)
Program for New Century Excellent Talents in University(No.2010ZD022)
