血清SA、EA-IgA、VCA-IgA、CgA联合检测对鼻咽癌诊断的临床价值

Diagnostic Value of Combined Measurement of Serum SA、EA-IgA、VCA-IgA and CgA Levels in Patients with Nasopharyngeal Carcinoma

目的探讨血清唾液酸(SA)、EB病毒早期抗原免疫球蛋白A(EA-IgA)、EB病毒壳抗原免疫球蛋白A(VCA-IgA)和嗜铬蛋白A(CgA)对鼻咽癌诊断的临床评价。方法对治疗前51例鼻咽癌患者进行SA、EA-IgA、VCA-IgA、CgA检测并与50例良性鼻炎及50例健康人作比较。结果以单一指标阳性作为诊断标准,SA、EA-IgA、VCA-IgA和CgA对鼻咽癌患者的敏感性分别为58.82%、31.37%、76.47%、74.51%,特异性分别为84.0%、96.0%、94.0%、54.0%。联合检测结果两项或两项以上阳性作为标准。本文中患者诊断灵敏度为96.08%、特异性为95%。结论联合检测血清SA、EA-IgA、VCA-IgA和CgA对鼻咽癌的辅助诊断有较高的临床实用价值。

Objective To study the diagnostic value of combined measurement of serum SA, EA-IgA, VCA-IgA and CgA Levels for Nasopharyngeal Carcinoma. Methods Serum SA, EA-IgA, VCA-IgA and CgA levels were measured in 51 patients with Nasopharyngeal Carcinoma , 50 patients with rhinitis and 50 controls. Results the sensitivity of SA, EA-IgA, VCA-IgA and CgA was 58.82% ,31.37% ,76.47% and 74.51% respectively , the specificity was 84.0% ,96.0% ,94.0% and 54.0% respectively. With combined detection of the four markers and assuming two or more markers positive as positive , the sensitivity would be 96.08% and specificity would be 95%. Conclusion Combined measurement of serum SA, EA-IgA, VCA-IgA and CgA levels is of clinical usefulness for diagnosis of Nasopharyngeal Carcinoma.