宫颈注射甲氨喋呤治疗未破裂输卵管妊娠临床分析

Clinical analysis of the injection MTX in cervix uteri on treatment of unruptured tubal pregnancy

目的探讨甲氨喋呤宫颈多点注射联合米非司酮治疗未破裂输卵管妊娠的临床效果。方法有生育要求的160例患者被随机分为两组。观察组用甲氨喋呤1mg/kg加入5ml注射用水中宫颈多点注射,同时口服米非司酮150mg/d连用3d,对照组单次静脉注射甲氨喋呤1mg/kg,同法加服米非司酮。对照两组保守成功率,输卵管复通率及不良反应。结果两组保守成功率分别为91%和82%,输卵管复通率分别为78%和60%。差异有统计学意义(P<0.05),药物不良反应无差异。结论宫颈多点注射甲氨喋呤治疗未破裂型输卵管妊娠方便、有效、安全,可常规应用于临床。

Objective To analysis the clinical results of multi-point injection MTX in cervix uteri companding mifepristone on treatment unrupture tubal pregnancy. Methods 160 requested ferticity patients were separated randomly into control group and eperimental gronp.90 patients of control group were given 1mg/kg MTX with 5ml water for multi-point injection and orally mifepristone 150 mg/d for three days.70 patients of experimental group were given singte intravenous inyection. The usage of mifepristone is same.To observe the cure ratios. the pateney-rate of uterine and the side effect. Results The cure ratios of two groups were 91%and 80%,The pateney-rate of uterine tubal were 78%and 60%.The differentes were signifficant （P〈0.05）. The side effect had no difference, Conclusion It is convenient, safe and effective of multi-point injection MTX into cervix uteri on theatment of unrupture tubal pregnancy.It can be used for routine clinical patients.