右美托咪啶对腹腔镜下直肠癌根治术后早期认知功能障碍的影响

Effects of Dexmedetomidine on Early Cognitive Impairment of Rectal Cancer Patients Treated with Laparoscopic Radical Resection

目的探究并分析右美托咪啶对腹腔镜下直肠癌根治术后患者早期认知功能障碍的影响。方法将60例直肠癌患者随机分为观察组和对照组,每组各30例。观察组术前、术中采取持续泵注右美托咪啶进行治疗,对照组术前、术中持续静脉泵注生理盐水。观察并比较两组患者术后MMSE评分及认知功能障碍的发生情况。结果观察组患者术后MMSE评分与术前比较变化不明显(P>0.05),而对照组患者术后MMSE评分明显低于术前,术后1 d、3 d观察组患者MMSE评分明显高于对照组患者;观察组患者术后认知功能障碍发生率为20.00%,明显低于对照组(53.33%);观察组认知障碍程度较对照组轻,P<0.05,具有统计学意义。术后两组认知功能障碍患者中感知障碍、学习及记忆障碍、思维障碍的发生率较为相近,两组无明显差异(P>0.05)。结论右美托咪啶对腹腔镜下直肠癌根治术后患者的认知功能障碍具有显著改善作用,值得在临床上广泛应用。

Objective To explore and analyze the effect of dexmedetomidine on early cognitive impairment of rectal cancer patients treated with laparoscopic radical resection. Methods 60 cases of rectal cancer patients were randomly divided in- to the observation group and the control group,30 cases in each. The observation group was treated with continuous pump infusion of dexmedetomidine before and during operation. The control group received continuous intravenous infusion of normal saline before and during operation. Postoperative MMSE score and the occurrence of cognitive dysfunction of the 2 groups were compared. Results Preoperative and postoperative MMSE scores of the observation group did not change significantly （ P 〉 0.05 ） , and in the control group,the postoperative MMSE score was significantly lower than that of preoperative; 1 d and 3 d after operation, MMSE scores of the observation group were significantly higher than that of the control group ; incidence rate of postoperative cog- nitive dysfunction of the observation group were 20.00% ,which was significantly lower than that of the control group （53.33%） ; the degree of cognitive impairment of the observation group was lighter than that of the control group,P 〈 0.05. Incidence rate of impaired perception,learning and memory disorders,mental disorders of postoperative cognitive dysfunction of the 2 groups were similar,there had no significant difference （P 〉 0.05）. Conclusion Dexmedetomidine is effective for cognitive dysfunction of rectal cancer patients treated with laparoscopic radical resection,and it should be widely used in clinical practice.