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植物内生菌在药物研究中的应用 被引量:7

The application of endophyte in drug research
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摘要 内生菌是指一类在其部分或全部生活史中存活于健康植物组织内部,而不使宿主植物表现出明显感染症状的微生物。几乎每种植物都有内生菌并且能够产生具有生物活性的天然代谢产物。本文综述了近几年来发现的具有不同生物功能的内生菌代谢产物及具有很大潜力的内生菌微生物转化作用。 Endophytes reside in the interior tissues of living plants,having no pathogenic effects on the hosts.They are found almost in every plant species and produce various novel natural metabolites that exhibit a variety of biological activities.This article mainly reviews the research progress on bioactive natural products from endophytes and their different functional roles.It also describes microbial transformation as potential method to obtain novel bioactive compounds from microbes.The prospect and problems of isolating natural products from endophytes are also discussed.
出处 《复旦学报(医学版)》 CAS CSCD 北大核心 2013年第5期610-618,共9页 Fudan University Journal of Medical Sciences
基金 国家重大新药创制专项(2009ZX09301-011)~~
关键词 内生菌 天然产物 抗肿瘤 抗菌 微生物转化 endophytes natural products anticancer antibacteriat microbial transformation
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