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SORL1基因与阿尔茨海默病相关性的研究现状 被引量：1

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摘要 阿尔茨海默病（Alzheimer＇s disease,AD）是最常见的痴呆类型,该病是与多基因有关的中枢神经系统的退行性疾病.AD的发病机制目前认为与遗传因素、细胞凋亡、自由基损伤等因素有关.AD的病理改变主要是累及前基底部发出至大脑皮质和海马的胆碱能神经通路,已知这些通路与注意、学习、记忆及其他认知过程有关.近年来研究发现,利用分子生物学技术,从DNA/RNA水平检测基因,分析基因结构变异和表达状态,从而对疾病在表型改变以前进行早期诊断.AD的发病率与年龄有关,随年龄增长而呈增加趋势[1-2].以65岁为界,AD可分为早发型（early-onest Alzheimer＇s disease,EOAD）和晚发型（late-onsets Alzheimer＇s disease,LOAD）两种.两型都有遗传学联系.流行病学研究表明,我国AD发病率约为1％左右,65岁以上发病率在3％ ～5％,并有逐年递增趋势.
作者 蔡晓平 董艳娟 张法军
机构地区 北京军区总医院干三科
出处 《脑与神经疾病杂志》 2013年第5期398-400,F0003,共4页 Journal of Brain and Nervous Diseases
关键词 L1基因 阿尔茨海默病 相关性 分子生物学技术 退行性疾病 中枢神经系统 神经通路 自由基损伤
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献26

  • 1Heun H,kolsch H,Jessen F. Risk factors and early signs ofAlzheimer's disease in family study sample. Risk of AD. Eur ArchPsychiatry Clin Neurosci, 2006,256 : 28-36.
  • 2Scarmeas N, Luchsinger JA, Schupf N,et al.Physical activity, diet,and risk of Alzheimer's disease. JAMA, 2009,302:627-637.
  • 3Goldgaber D,Lerman M I,McBride 0 W, et al. Characterization andchromosomal location of a cDNA encoding brain amyloid ofAlzheimer's disease.Science, 1987,235 ;877-880.
  • 4Kang J, Lemaire HG, Unterbeck A, et al. The precursor ofAlzheimer's disease amyloid A4 protein resembles a cell - surfacereceptor.Nature, 1987,25 : 733-736.
  • 5吴林林,白燕,许秀峰.迟发型阿尔茨海默病的基因研究进展[J].医学综述,2011,17(2):192-194. 被引量：2
  • 6Jacobsen L,Madsen P, Jacobsen C, et al. Activation and functionalcharacterization of the mosaic reoeotor SorlA / LR 1 1. J Bio] Chem,2001,276: 22788-22796.
  • 7Rogaeva E,Meng Y, Lee JH,et al. The neuronal sortilin-relatedreceptoe SORL 1 is genetically associated with Alzheimer's disase.Nat G enet, 2007, 39 :J68-177.
  • 8Poon WW, Blurton - Jones M, Tu CH, et al.axonal BDNF retrograde trafficking, Neurobiol Aging, 2011, 32.:821-833.
  • 9Chavant F, Deguil J, Pain S, et al. Imipramine, in part throughtumor necrosis factor alpha inhibition,prevents cognitive declineand beta - amyloid accumulation in a mouse model of Alzheimer、disease.J Phannacol Exp Ther,2010, 332:505-514.
  • 10Armstrong RA. Spatial patterns of p - amyloid (A)deposits infamilial and sporadic Alzheimer.s disease. Folia Neuropathol, 2011,49:153-161.

二级参考文献21

  • 1Corder EH, Saunders AM, Strittmatter WJ,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families [ J ]. Science, 1993,261 ( 5123 ) : 921-923.
  • 2Gatz M, Reynolds CA, Fratiglioni L, et al. Role of genes and environments for explaining Alzheimer disease [ J]. Arch Gen Psychiatry,2006,63 (2) :163-174.
  • 3Siest G, Pillot T, Regis-Bailly A, et al. Apolipoprotein E : an important gene and protein to follow in latoratory medicine [ J ]. Clin chem, 1995,41 ( 8 Pt 1 ) : 1068-1086.
  • 4Caselli RJ, Dueck AC, Osborne D, et al. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect [ J ]. N Engl J Med, 2009,361 ( 3 ) : 255-263.
  • 5Dumanis SB, Tesoriero JA, Babus LW, et al. ApoE 4 decreases spine density and dendritic complexity in cortical neurons in vivo [ J]. J Neurosci ,2009,29 (48) : 15317-15322.
  • 6Zhong N, Ramaswamy G, Weisgraber KH, et al. Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function [J ]. Biol Chem, 2009, 284 (40) : 27273 -27280.
  • 7Panchal M, Loeper J, Cossee JC,et al. Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry[ J]. J Lipid Res ,2009,51 ( 3 ) :598-605.
  • 8Li G,Bien-Ly N,Andrews-Zwilling Y,et al. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice[J]. Cell Stem Ce11,2009,5(6) :634-645.
  • 9Nilsson K, Gustafson L, Nornholm M, et al. Plasma homoeysteine, apolipoprotein E status and vascular disease in elderly patients with mental illness[ J ]. Clincle Chem Lab Med ,2010,48 ( 1 ) : 129-135.
  • 10Tesseur I,Zhang H, Brecht W, et al. Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3 [ J ]. J Neurochem, 2009,110 (4) : 1254-1262.

共引文献1

同被引文献19

  • 1Takahashi M, Bujob H, Jiangb M, et at.. Enhanced circulating soluble LRll in patients with coronary or- ganic stenosis[J]. Atherosclerosis, 2010,210 ( 2 ) : 581- 584.
  • 2Fujimura K, Ebinuma H, Fukamachi I, et al.. Circu- lating LR11 is a novel soluble-receptor marker for ear- ly-stage clinical conditions in patients with non- Hodgkin' s lymphoma[J]. Clin Chim Acta, 2014,430 .. 48-54.
  • 3Takahashi M, Bujo H, Jiang M, et al.. Enhanced cir- culating soluble LRll in patients with diabetic retinop- athy[J]. Am J Ophthalmol, 2012,154(1) .. 187-192.
  • 4Jiang M, Bujo H, Ohwaki K, et al.. Ang II-stimulated migration of vascular smooth muscle ceils is dependent on LR11 in mice [J]. J Clin Invest, 2008, 118 (8) 2733-2746.
  • 50hwaki K, Bujo H, Jiang M, et at.. A secreted soluble from of LR11, specifically expressed in intimal smooth muscle cells, accelerates a formation of lipid-laden macrophages [J]. Arterioscler Thromb Vasc Biol , 2007,27(5) : 1050-1056.
  • 6Zhu Y, Bujo H, Yamazaki H, et al..LR11, an LDL re- ceptor gene family member, is a novel regulator of smooth muscle cell migration[J]. Circ Res, 2004,94 (6) :752-758.
  • 7McCarthy C, O'Gaorab P, Jamesa WG, et al.. SorLA modulates atheroprotective properties of CLA by regula- ting monocyte migration [J]. Atherosclerosis, 2010, 213 400-407.
  • 8Rogaeva E, Meng Y, Lee JH, et al.. The neuronal sor- tilin-related receptor SORL I is genetically associated with Alzheimer s disease[J]. Nat Genet, 2007,39 (2) .. 168-177.
  • 9Ogita M, Miyauchi K, Dohi T, et al.. Increased circu- lating soluble LRll in patients with acute coronary syn- drome[J]. Clin Chim Acta ,2013,415 : 191-194.
  • 10Ogita M, Miyauchi K, Jiang M, et al.. Circulating sol- uble LRll, a novel marker of smooth muscle cell prolif- eration, is enhanced after coronary stenting in response to vascular injury[J]. Atherosclerosis, 2014, 237 (1) .. 374-378.

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脑与神经疾病杂志
2013年 第5期

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