促胃肠动力药在便秘患者结肠镜检查前肠道清洁中的作用

Role of mosapride in improvement of bowel preparation before colonoscopy in patients with constipation

目的:探讨促胃肠动力药(莫沙必利)在便秘患者结肠镜检查前肠道清洁中的作用.方法:结肠镜检查的慢性便秘患者90例,采用随机数字表法分为A组(聚乙二醇溶液)、B组(莫沙必利+聚乙二醇溶液)和C组(莫沙必利),每组30例.比较3组患者肠腔清洁程度和服用药物后的安全性.结果:C组(7.13±1.12)、B组(6.65±1.18)结肠清洁程度总分均高于A组(5.81±1.19)评分(Benferroni检验均P<0.05);C组排便总次数多于A组(7.15±1.61 vs 6.54±1.52),差异有统计学意义(t=2.724,P=0.023),3组结肠腔内气泡情况差异未见统计显著性(F=0.359,P=0.699).A、B、C 3组不良反应总发生率分别为16.67%(5/30)、13.33%(4/30)和6.67%(2/30),差异未见统计学意义(χ2=1.450,P=0.484).结论:结肠镜检查前应用促胃肠动力药可以有效提高肠腔的清洁程度,较大剂量应用效果较好.

AIM： To investigate the role of mosapride in improvement of bowel preparation before colonoscopy in patients with constipation. METHODS： Ninety patients with chronic constipation who requested colonoscopy were randomly and equally divided into three groups： A, B and C. Group A was given polyethylene glycol solution, group B was treated by mosapride plus polyethylene glycol solution, and group C was given mosapride alone. The extent of intestinal cleanliness and the incidence of side effects were compared between the three groups.RESULTS： The colon cleaning score was significantly higher in groups C and B than in group A （7.13 ± 1.12, 6.65 ± 1.18 vs 5.81 ± 1.19, both P 〈 0.05）. The frequency of bowel movement in group C was significantly higher than that in group A （7.15 ± 1.61 vs 6.54 ± 1.52, t = 2.724, P = 0.023）. The intestinal bubble score showed no statistically significant difference among the three groups （F = 0.359, P = 0.699）. The incidence of side effects also did not differ significantly among the three groups （16.67%, 13.33% and 6.67%, χ2 = 1.450, P = 0.484）. CONCLUSION： Mosapride can effectively improve bowel preparation before colonoscopy in patients with constipation.