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高密度脂蛋白抗感染的研究进展 被引量：6

Progress of anti-infection of high density lipoprotein
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摘要 细菌感染易发展为脓毒症,这被视为有较高病死率的最主要原因。高密度脂蛋白及其相关载脂蛋白能与脂多糖结合,调节机体炎症反应,降低病死率,有望为抗细菌感染的治疗提供新的思路。 Bacterial infection is likely to develop into sepsis, which is regarded as the main reason for high mortality rate. High-density lipoprotein cholesterol （HDL-C） and its associated apolipoprotein can combine with lipopolysaccharide, regulate the body＇s inflammatory response and reduce the mortality, which can provide a new method for treatment of bacterial infection.
作者 郭琪 邹国英
机构地区 湖南省脑科医院检验科 湖南中医药大学医学检验教研室
出处 《中南大学学报（医学版）》 CAS CSCD 北大核心 2013年第9期954-958,共5页 Journal of Central South University ：Medical Science
基金 湖南省脑科医院院级课题基金(2012) 湖南省脑科医院重点专科建设基金(2011)~~
关键词 细菌感染 高密度脂蛋白 载脂蛋白 脂多糖 bacterial infection high-density lipoprotein cholesterol apolipoprotein lipopolysaccharide
分类号 R459.7 [医药卫生—急诊医学]
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参考文献33

  • 1Khovidhunkit W, Kim MS, Memon RA, et al.Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host[J].J Lipid Res, 2004, 45(7): 1169-1196.
  • 2Karlsson H, Leanderson P, Tagesson C, et al.Lipoproteomics II: Mapping of proteins in high-density lipoprotein using two-dimensional gel electrophoresis and mass spectrometry[J] .Proteomics, 2005, 5(5): 1431-1445.
  • 3Suzuki M, Pritchard DK, Becker L, et al.High-density lipoprotein suppresses the Type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide[J].Circulation, 2010, 122(19): 1919-1927.
  • 4Premtip T, Wanee P, Worakamol NU, et al.Effects of human apolipoprotein A- I on endotoxin-induced leukocyte adhesion on endothelial cells in vivo and on the growth of Escherichia coli in vitro[J].J Endotoxin Res, 2007, 13(1): 58-64.
  • 5Levels JH, Abraham PR, van den Ende A, et al.Distribution and kinetics of lipo- protein- bound endotoxin[J].Infect Immun, 2001, 69(5): 2821-2828.
  • 6Levels JH, Abraham PR, van Barreveld EP, et al.Distribution and kinetics of lipoprotein-bound lipoteichoic acid.[J].Infect Immun, 2003, 71(6): 3280-3284.
  • 7Berbee JF, Havekes LM, Rensen PC.Apolipoproteins modulate the inflammatory response to lipopolysaccharide[J].J Endotoxin Res, 2005, 11(2): 97-103.
  • 8van Leeuwen HJ, Heezius EC, Dallinga GM, et al.Lipoprotein metabolism in patients with severe sepsis[J].Crit Care Med, 2003, 31(5): 1359-1366.
  • 9Henning MF, Herlax V, Bakas L.Contribution of the C-terminal end of apolipoprotein AI to neutralization of lipopolysaccharide endotoxic effect[J].Innate Immunity , 2011, 17(3): 327-337.
  • 10Linthout SV, Spillmann F, Graiani G, et al.Down-regulation of endothelial TLR4 signalling after apoA-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation[J].J Mol Med, 2011, 89(2): 151-160.

同被引文献89

  • 1鞠剑峰,李澄俊,徐铭.纳米Ag/TiO_2复合材料的抗菌性能[J].精细化工,2005,22(1):59-61. 被引量：35
  • 2Shin HR,Carlos MC,Varghese C.Cancer control in the Asia Pa cific region:current status and concerns[J].Jpn J Clin Oncol,2012,42(10):867-881.
  • 3Hu J,La Vecchia C,de Groh M,et al.Dietary cholesterol intake and cancer[J].Ann Oncol,2012,23(2):491-500.
  • 4Ahern TP,Pedersen L,Tarp M,et al.Statin prescriptions and breast cancer recurrence risk:a Danish nationwide prospective cohort study[J].J Natl Cancer Inst,2011,103 (19):1461-1468.
  • 5Kitayama J,Hatano K,Kaisaki S,et al.Hyperlipidaemia is posi tively correlated with lymph node metastasis in men with early gastric cancer[J].Br J Surg,2004,91 (2):191-198.
  • 6Dilman VM,Berstein LM,Ostroumova MN,et al.Peculiarities of hyperlipidaemia in tumour patients[J].Br J Cancer,1981,43(5):637-643.
  • 7Kitahara CM,Berrington de González A,Freedman ND,et al.Total cholesterol and cancer risk in a large prospective study in Ko rea.J Clin Oncol,2011,29(12):1592-1598.
  • 8Iso H,Ikeda A,Inoue M,et al.Serum cholesterol levels in rela tion to the incidence of cancer:the JPHC study cohorts[J].Int J Cancer,2009,125 (11):2679-2686.
  • 9BerbéeJF,vanderHoogtCC,Kleemann R,etal.Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis[J].FASEB J,2006,20 (12):2162-2164.
  • 10Barter P,McPherson YR,Song K,et al.Serum insulin and inflam matory markers in overweight individuals with and without dyslipidemia[J].J Clin Endocrinol Metab,2007,92(6):2041-2045.

引证文献6

二级引证文献29

中南大学学报（医学版）
2013年 第9期

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