银杏达莫注射液联合巴曲酶治疗脑梗死疗效的Meta分析

Efficacy of combination of Yinxin Damo Injection and batroxobin for cerebral infraction: a Meta-analysis

目的系统评价银杏达莫注射液联合巴曲酶治疗脑梗死的临床疗效。方法计算机检索Pubmed、Cochrane图书馆、中国学术文献出版总库(CNKI)、维普电子期刊全文数据库(VIP)、万方数据库、中国生物医学文献数据库(CBM)等。2名评价员独立评价纳入研究的质量并提取资料,使用RevMan 5.0软件进行统计分析。结果共纳入14个研究,共1 302例患者。Meta分析结果显示:银杏达莫联合巴曲酶能提高脑梗死患者治疗的总有效率[OR=4.22,95%CI(2.87,6.20),P<0.000 01]和总显效率[OR=2.79,95%CI(2.12,3.68),P<0.000 01],降低神经功能缺损评分[MD=-3.19,95%CI(-4.21,-2.17),P<0.000 01]和美国国立卫生院卒中量表评分[MD=-2.67,95%CI(-3.55,-1.79),P<0.000 01],降低纤维蛋白原水平[MD=-0.54,95%CI(-0.89,-0.19),P=0.003]。结论银杏达莫注射液联合巴曲酶能使脑梗死患者受益,但尚待大规模、高质量的研究加以验证。

AIM To assess the efficacy of Yinxin Damo Injection associated with batroxobin for cerebral infrac- tion. METHODS Database including Pubmed, The Cochrane Library, CNKI, VIP, Wangfang Database and CBM were searched for randomly controlled trails （RCTs）. The quality of included RCTs was evaluated and the da- ta were collected by two evaluators independently. Meta-analysis was performed using RevMan 5.0. RESULTS Fourteen RCTs involving 1 302 participants were included. The results of Meta-analysis indicated that Yinxin Damo Injection associated with batroxobin could increase the efficiency [ OR = 4. 22, 95% CI （ 2. 87, 6. 20 ）, P 〈 0. 000 01 ] and obvious effective rate [ OR = 2.79, 95% CI （2. 12, 3.68）, P 〈 0. 000 01 ] on cerebral infrac- tion, decrease the neurological deficit scores [MD = -3.19, 95% CI （ -4. 21, -2. 17）, P 〈0. 000 01 ], Na- tional Institute of Health stroke scale [ MD = -2. 67, 95% CI （ -3.55, - 1.79）, P 〈0. 000 01 ] and lower the fibrinogen level [ MD = - 0. 54, 95% CI （ - 0. 89, - 0. 19 ）, P = 0. 003 ]. CONCLUSION Combination of Yinxin Damo Injection and bartroxobin could benefit the patients with cerebral infraction, but the conclusion needs to be verified by protocols of more samples and high quality.