取代苯氧基-3-乙酰吡啶类中间体的合成

Synthesis of substituted phenoxy-3-acetylpyridine intermediates

由6-氯烟酸出发经两步合成了16个苯氧基-3-乙酰吡啶类中间体,其中14个为新化合物。通过改变缚酸剂缩短了反应时间,提高了收率,与现有文献报道的合成方法相比,具有步骤少、反应时间短、收率高的优点。产物结构经核磁、质谱表征得到确认。

16 Different phenoxy-3-acetylpyridine intermediates was synthesized by two steps starting from 6-ehloronicotinic acid, 14 of which are new compounds. This method can short- en the reaction time and improve the yield by changing the acid-binding agent. Compared with literature methods, this method has the advantages of shorter steps and reaction time, and high yield. The structure of the products were confirmed by 1HNMR,MS.