乙肝病毒载量与妊娠期糖尿病关系的研究

Relationship between hepatitis B viral load and gestational diabetes mellitus

目的探讨乙肝病毒载量与妊娠期糖尿病的相关性。方法选取2011年1月1日到2012年12月31日来石家庄市妇幼保健院进行分娩的产妇13 565例,其中按照是否携带乙肝病毒将其分为未携带乙肝病毒(A)组10 641例和携带乙肝病毒(B)组2 924例。在B组中,再按照HBV-DNA的载量不同分为HBV-DNA含量阳性(B1)组(≥5×10~2IU/mL)及HBV-DNA含量阴性(B2)组(<5×10~2IU/mL),对比A、B两组的妊娠期糖尿病发生率,及B1、B2两组的妊娠期糖尿病发生率。结果 B组妊娠期糖尿病的发生率为10.29%(301/2 924)、A组妊娠期糖尿病的发生率为0.96%(102/10 641),B组妊娠期糖尿病妊娠期糖尿病的发生率显著大于A组(x^2=369.990,P<0.05);而B1、B2两组妊娠期糖尿病的发生率比较差异无统计学意义(z=0.296,P>0.05).结论 乙肝病毒携带与妊娠期糖尿病的发生有关,乙肝病毒载量与妊娠期糖尿病的发生无性。

Objective To discuss the correlation between hepatitis B viral load and gestational diabetes mellitus （GDM）. Methods From January 1 in 2011 to December 31 in 2012, totally 13 565 pregnant women who hospitalized in Maternal and Child Care Service Center of Shijiazhuang City for delivery were divided into non-hepatitis B virus group （group A） and hepatitis B virus group （group B）. There were 10 641 cases in group A and 2 924 cases in group B. Group B was further divided into group B1, namely HBV-DNA content positive group（/〉 5 x 102IU/mL） and group B2, namely HBV-DNA content negative group（ 〈 5 x 102IU/mL）. The incidence rate of GDM was compared between group A and group B, as well as group B1 and group B2. Results The incidence rate of GDM in group B and group A was 10.29% （301/2 924） and 2.36% （251/10 641 ）, respectively, and it was significantly higher in group B（X2 = 369. 990, P 〈 0.05）. However, the difference in the incidence rate of GDM between group B1 and group B2 was not significant（z = 0. 296, P = 0. 852 〉 0.05 ）. Conclusion Carrier of hepatitis B virus has significant correlation with GDM, while hepatitis B viral load has no close correlation with GDM.