原发性高血压患者动态血压检测指标与肾损害的相关性研究

The correlation research of the index of ambulatory blood pressure and renal damage in patients with primary hypertension

目的：探讨原发性高血压患者血压昼夜节律异常与动脉硬化指数及肾损害的关系。方法：选取原发性高血压患者113例，按照24h动态血压检测结果分为非杓形组66例和杓形组47例。分别检测动脉硬化指数、尿微量白蛋白、24h尿蛋白定量及肾功能情况。观察高血压患者血压昼夜节律异常与动脉硬化指数及。肾损害的关系。结果：非杓形组夜间收缩压及舒张压明显高于杓形组（P〈0．01），2组的动脉硬化指数、脉压、血压昼夜变化率差异均有统计学意义（P〈0．01），2组患者的血尿素氮、血胱抑素、血肌酐、尿微量白蛋白差异均有统计学意义（P〈0．05～P〈0．01），而血尿酸差异无统计学意义（P〉0．05）。结论：原发性高血压患者血压昼夜节律异常与动脉硬化指数及肾脏损害有关，非杓型者更为显著。

Objective：To investigate the relationship of abnormal circadian rhythm blood pressure （BP）, arterial stiffness index and renal damage in patients with primary hypertension. Methods： One hundred and thirteen patients with primary hypertension were divided into non-scoop shape group （66 cases ） and scoop shape group （47 cases ）. The arterial stiffness index, urinary microalbuminuria ,24 h quantity of urinary protein and renal function of two group were detected. The relationships of abnormal circadian rhythm BP, arterial stiffness index and renal damage in patients with primary hypertension were observed. Results：The nocturnal systolic and diastolic blood pressure in non-scoop shape group were significantly higher than those in scoop shape group （ P 〈 O. O1 ）. The differences of arterial stiffness index, pulse pressure and blood pressure circadian rhythm variations in two groups were statistically significant （P 〈 0.01 ）. The differences of blood urea nitrogen, serum cystatin, serum creatinine and microalbuminuria in two groups were statistically significant（ P 〈 0.05 to P 〈 0. 01 ）, but no statistical significance in the difference of blood uric acid （ P 〉 0. 05 ）. Conelusiorts：There have relationships between abnormal circadian rhythm BP, arterial stiffness index and renal damage in patients with primary hypertension, it is more significant in non-scoop shape group.