慢性酒精中毒患者认知功能障碍的评估

The evaluation of cognitive dysfunction in patients with chronic alcoholism

目的:探讨蒙特利尔认知评估量表(MoCA)和简易智能状态量表(MMSE)联合测评慢性酒精中毒(chronic alcoholism,CA)患者轻度认知功能障碍(MCI)可行性及敏感性。方法:应用MoCA和MMSE分别测评60例CA患者(CA组)和30名健康体检者(对照组)的认知功能。结果:CA组和对照组MMSE和MoCA评分间差异均有统计学意义(P<0.01),2组在视空间、记忆力和反应能力差异均有统计学意义(P<0.01)。结论:MoCA和MMSE联合应用可能有利于早发现CA患者的MCI,MoCA在记忆和局部认知领域缺损敏感性测评优于MMSE,MoCA可为CA患者认知障碍的早期发现和防治提供无创性筛选依据。

Objective：To investigate the feasibility and sensitivity of Montreal cognitive assessment （MoCA） and mini-mental state examination（MMSE） in the evaluation of mild cognitive impairment （MCI） in patients with chronic alcoholism（CA）. Methods ：The cognitive function of 60 patients with CA（ CA group） and 30 healthy people（ control group） were evaluated by MoCA and MMSE. Results：The differences of the scores of MoCA and MMSE between CA group and control group were statistically significant （P 〈 0.01 ）. The differences of the visual space and memory and reaction abilities in two groups were statistically significant（P 〈 0.01 ）. Conclusions ：The federated applications of MoCA and MMSE are beneficial to find the MCI patients with CA in the early stage. The memory and sensitivity of the impairment in local cognitive domain evaluated by MoCA are better than MMSE. MoCA can provide an evidence for early finding, preventing and treating the cognitive impairment in patients with CA.