高纯度(>99%)6-羟基犬尿喹啉酸的合成

Synthesis of 6-Hydroxykynurenic Acid with High Purity( > 99%)

以丁炔二羧酸二甲酯和对氨基苯酚为原料,经迈克尔加成、环合和碱水解反应合成了6-羟基犬尿喹啉酸,总收率43.3%,纯度>99%,其结构经1H NMR,13C NMR和HR-MS确认。

6-Hydroxykynurenic acid was synthesized from 4-aminophenol and dimethyl acetylenedicarboxylate by Michael addition,cyclization and basic hydrolysis.The total yield was 43.3％ and purity was ＞99％.The structure was confirmed by 1H NMR,13C NMR and HR-MS.