抗病毒药物的毒性及残留检测方法研究进展

Research Development of Toxicity and Residue Detection Methods of the Antiviral Drugs

就曾试用于兽医临床而后又被禁用的金刚烷胺、金刚乙胺、利巴韦林、阿昔洛韦和吗啉胍等常见抗病毒药物的理化性质、代谢、毒性以及残留检测方法等四个方面的研究进展进行了综述。

Some criminals used Amantadine, Rimantadine, Ribavirin, Aciclovir and Moroxydine to prevent and treat animal diseases. These drugs which were used with more dosage for long term may lead to animal poisoning, immunity suppression, resistance and drug residue, even difficulty in controlling animal diseases. Amantadine residue was detected in chicken in speed-up chicken affair in 2012, which had negative impact on our national poultry industry. This paper summarized the research development of the physical and chemical character, metabolism, toxicity and residue detection methods of these drugs.