摘要
目的探讨郎格罕细胞组织细胞增生症(LCH)的临床病理特点,提高对其认识,减少误诊。方法 2例郎格罕细胞组织细胞增生症患者,用HE及免疫组化的方法分析其临床、病理及免疫特色。结果病理形态LCH细胞大,圆形或卵圆形,胞质丰富略嗜酸性,有的核偏位可见核沟,伴嗜酸性粒细胞浸润。免疫组化示:CD1a(+),S-100(+),HLA-DR部分(+)。结论 2例患者现恢复良好,但此类肿瘤生物学行为不确定故仍建议密切随访。病理检查细胞核形态有特异性,明确诊断需CD1a(+),S-100(+)。
Objective To investigate the clinical and pathological features of langerhans cell histiocytosis(LCH). Methods The 2 cases of LCH were analyzed about the features of clinic, pathology and immunohistochemisty. Results LCH cell with abundant eosinophilic cytoplasms, and longitudinally grooved or reniform nuclei .Lyrnphocytes and a few eosinophils also could be seen. Two cases showed that the langerhans cell were with pale cytoplasms, there were numerous eosinophils cells. The immunity displayed that CDla (+),S-100 (+),HLA-DR (+). Conclusions A diagnosis of LCH was made based on clinical manifestation and histopathological features, both CDla (+) and S-100 (+) were needed. The prognosis was almost good and need foUow-up.
出处
《中国医药指南》
2013年第26期4-6,共3页
Guide of China Medicine