游泳对新生儿黄疸的作用及相关机制研究

Research of the effects and related mechanism about swimming applied to the neonatal jaundice

目的研究游泳对新生儿黄疸的作用及相关机制。方法选取2012年1月-2013年1月汕尾市人民医院出生5d内的新生儿120例，分为游泳组及对照组，每组各60例，分别采用游泳以及常规沐浴方式干预黄疸。对两组干预后黄疸指数、黄疸消退时间、胆红素水平、胃泌素水平、IgA、IgG、IgM与白细胞介素-6（IL-6）、白细胞介素-8（IL-8）情况及外周血T淋巴细亚群情况分别进行比较。结果①两组第1天黄疸指数差异无统计学意义（P〉0．05）；游泳组第3、7天黄疸指数低于对照组，差异有统计学意义（P〈0．05）；另外，游泳组新生儿黄疸消退时间短于对照组（P〈0．05）。②游泳组新生儿血胆红素水平[（134．2±31．6）μmol／L]低于对照组[（169．7±45．3）μmol/L]，血清胃泌素水平[（112．4±33．7）ng/L]高于对照组[（102．6±25．4）ng/L]，差异均有统计学意义（P〈0．05）。③游泳组新生儿在血浆IgA、IgG、IgM、IL-6、IL-8等指标均明显高于对照组．差异均有统计学意义（P〈0．05）。④游泳组新生儿CD3＋、CD4＋以及CD4＋/CD8＋等指标高于对照组，差异均有统计学意义（P〈0．05）；两组CD8＋差异无统计学意义（P〉0．05）。结论游泳对新生儿黄疽具有明显的改善作用，安全性高，并利于提高新生儿的免疫功能，值得临床推广。

Objective To research the effects and related mechanism about swimming applied to the neonatal jaundice. Methods 120 cases of newborn babies within 5 days in People＇s Hospital of Shanwei City from January 2012 to January 2013 were selected and divided into swimming group and control group with 60 cases in each group, swimming and routine bathing were used in swimming group and control group respectively. The jaundice index, time of jaundice subsided, bilirubin levels, gastric secrete element levels and immune function and the IgA, IgG, IgM, IL-6, IL-8, peripheral blood T lymphocyte subsets of two groups were compared. Results ①The difference of jaundice index of the two groups in the 1st day was not statistically significant （P 〉 0.05）; the jaundice index of the swimming group in the 3rd, 7th day were all lower than those of the control group, the differences were statistically significant （P 〈 0.05）; time of jaundice subsided in swimming group was shorter than that in control group （P 〈 0.05）. ②Bilirubin levels of swimming group [（134.2±31.6） μmol/L] was lower than that of control group [（169.7±45.3） μmol/L], gastric secrete element levels of swimming group [（112.4±33.7） ng/L] was higher than that of control group [（102.6±25.4） ng/L], the differences were statistically significant （P 〈 0.05）. ③IgA, IgG, IgM, IL-6, IL-8 in swimming group were higher than those in control group, the differences were statistically significant （P 〈 0.05）. ④CD3＋, CD4＋, CD4＋/CD8＋ in swimming group were higher than those in control group, the differences were statistically significant （P 〈 0.05）; the difference of CD8＋ in the two groups was not statistically significant （P 〉 0.05）. Conclusion Swimming applied to the neonatal jaundice has obvious improving effect and high safety, and swimming can improve the immune function of new- born babies, the clinical can promote widely.