路优泰治疗脊髓损伤后抑郁焦虑的临床疗效

Clinical Effect of Neurostan in the Treatment of Depression and Anxiety after Spinal Cord Injury

目的路优泰治疗脊髓损伤后抑郁焦虑症状的临床疗效。方法按照数字随机法把78例患者分为实验组40例和对照组38例,两组患者均给予综合康复治疗措施,两组患者治疗时间,训练强度均一致;实验组同时并用路优泰片300 mg,每日3次,疗程4 w。治疗前及治疗后分别记录患者HAMD评分、HAMA评分及改良Barthel指数评分。结果两组患者一般资料、HAMD评分、HAMA评分及改良Barthel指数评分在治疗前无显著性差异(P>0.05),康复治疗4 w后,两组患者的HAMD评分、HAMA评分及改良Barthel指数评分较治疗前有显著性差异(P<0.05),并且实验组的评分高于对照组(P<0.05)。结论路优泰能够改善脊髓损伤后患者抑郁焦虑状态,提高患者的日常生活能力。

Objective To observe the clinical effect of Neurostan in the treatment of depression and anxiety after spi- nal cord injury. Methods 78 patients were randomly divided into two groups： the experimental group （40 cases） and the control group （38 cases）. Both groups were given a comprehensive rehabilitation treatment, with the same treatment time and training intensity. The experimental group took Neurostan 300 mg J times a day for 4 weeks. Before and after the treat- ment, patients＇ HAMD scores were recorded, together with HAMA scores and modified Barthel index scores respectively. Results There was no significant difference （ P 〉 0. 05 ） in two groups＇ general information, HAMD scores, HAMA scores and modified Barthel index scores before treatment. However, after 4 weeks＇ treatment, the HAMD scores, HAMA scores and modified Barthel index scores of the two groups were significantly different （ P 〈 0.05 ） , and the experimental group scored higher than the control group （ P 〈 0. 05 ）. Conclusion Neurostan can get depression and anxiety alleviated after spinal cord injury, enhance the daily living ability of the patients.