药物治疗74例反流性食管炎的临床分析

Clinical analysis of 74 cases of reflux esophagitis drug treatment

目的比较奥美拉唑和雷贝拉唑治疗反流性食管炎的临床分析。方法选择2010年9月到2012年7月来我院消化科住院治疗反流性食管炎患者74例,随机分为两组:A组给予雷贝拉唑10 mg/d,西沙比利10 mg/d;B组给予奥美拉唑20mg/d,西沙比利10 mg/d。两组均用药8周。观察两组临床症状、胃镜下炎症愈合的变化。结果两组相比A组能更加迅速地缓解症状,两组间差异有统计学意义(P<0.05)。并且1个月时胃镜下炎症愈合率A组亦明显优于B组,两组间差异有统计学意义(P<0.05)。结论雷贝拉唑与奥美拉唑相比能更快缓解反流性食管炎的临床症状,加快炎症愈合。

Objective To compare the clinical effects of the omeprazole and rabeprazole in treatment of reflux esophagitis. Methods 74 cases were randomly divided into two groups： The subjects of group A were given rabeprazole 10 rag/d, cisapride 10 rag/d; the subjects of group B were given omeprazole 20 rag/d, Cisaprid 10mg/d. Observe the clinical effects and the changes of inflammation under gastroscopy between the two groups. Results The clinical symptoms could be relieved much more fast in the observation group and the difference was statistically significant（P〈0.05）. The rate of the healing of inflammation in the observation group was higher than the control group too, the difference was statistically significant（P〈0.05）.Conclusion Compared with omeprazole, rabeprazole can quickly relieve the clinical symptoms of esophagitis reflux and speed up the healing of inflammation.