老年人非甾体抗炎药相关上消化道出血的临床特点分析

Clinical features of upper gastrointestinal bleeding associated with non-steroidal anti-inflammatory drug among elder patients

目的探讨非甾体抗炎药(NSAIDs)所致上消化道出血的临床特点。方法收集顺义区医院2006年3月到2011年3月5年间收治的60岁以上确诊为上消化道出血的住院患者,根据是否服用NSAIDs分为两组,比较两组的出血特点。结果 NSAIDs组更容易合并呕血,出血量大,出血前多无腹痛等症状,平均住院次数多于非NSAIDs组,更容易合并冠心病、脑血管等疾病(P<0.001)。两组在住院天数、是否输血、是否合并休克、出血季节、溃疡的发生部位等方面无统计学差异(P>0.05)。结论重视服用NSAIDs的老年患者出血,采取措施预防NSAIDs的胃肠道不良反应。

Objective To investigate the clinical features of upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs （NSAIDs）. Methods Hospitalized patients were included in the study who were diagnosed as upper gastrointestinal bleeding and over 60 during March 2006 to March 2011 in Shunyi District Hospital. All cases were Divided into two groups according to whether taking NSAIDs and the bleeding characteristics were compared. Results The prevalence of coronary heart disease, cerebrovascular disease in NSAIDs group were significantly higher than non-NSAIDs group（P 〈0.001）The NSAIDs group showed vomiting, large amount of bleeding, no more pain before bleeding. The frequency of hospitalization was significantly higher than in non-NSA/Ds group. There were no significant differences in hospital day, blood transfusion, shock, bleeding season and ulcer site（P〉0.05）. Conclusion Elderly patients should pay more attention to the prevention of gastrointestinal adverse reactions especially the elderly taking NSAIDs.