白芍总苷联合窄谱中波紫外线治疗寻常性银屑病临床观察

Clinical observation of TGPwith narrowband ultraviolet B in the treatment of psoriasis vulgaris

目的观察白芍总苷联合窄谱中波紫外线治疗寻常性银屑病(PV)的疗效及不良反应。方法采用随机对照临床试验,将68例符合纳入标准的患者分为2组,治疗组(A组)及对照组(B组)各34例,A组使用白芍总苷1.8 g/d加窄谱中波紫外线照射、B组单用窄谱中波紫外线照射,疗程均为8周。治疗前、治疗后4、8周检查2组患者的血、尿、大便常规及肝、肾功能,同时观察患者的不良反应。结果 A组有效率为87.88%;B组有效率为63.64%,两组有效率比较差异有统计学意义(P<0.05),所有患者均未出现严重不良反应。结论白芍总苷联合窄谱中波紫外线治疗PV疗效明显,且不良反应少,安全性高。

Objective To observe the therapeutic effect and adverse reactions of total glucosides of paeony capsules（TGP） with narrowband ultraviolet B（NB-UVB） in treatment of psoriasis vulgaris.Metbods A randomized controlled clinical trial was conducted.Sixty-eight patients were randomized into the treatment group（n=34）and the control groups （n=34）.The treatment group was treated with TGP（1.8g daily） and NB-UVB （Group A）.Control group was treated with NB-UVB （GroupB）.Blood routine,urine and stool routine,liver and kidney function in all patients were detected before and after 4 and 8 weeks treatment.In addition,adverse reactions were monitored.Results The effectiv rate was 87.88% for group A and 63.64%,for group B.There was significant difference between group A and B（P〈0.05）. No serious adverse events were recorded in both groups.Conclusion Compared with NB-UVB alone,TGP combined with NB-UVB has better effective in treatment of psoriasis vulgaris with fewer side effects and good safety.