高频振荡通气治疗新生儿重症呼吸衰竭的临床分析

Clinical analysis of high-frequency oscillatory ventilation in treatment of severe respiratory failure in newborns

目的 探讨高频振荡通气治疗新生儿重症呼吸衰竭的临床疗效.方法 选择2009年1月～2013年1月本院新生儿重症监护室收治的85例重症呼吸衰竭患儿,随机分为对照组42例及观察组43例,分别采用常规机械通气及高频振荡通气治疗,观察治疗效果.结果 对照组上机时间明显长于观察组;观察组在治疗后6、12、24 h,FiO2及PaCO2较对照组下降更明显,a/APO2在治疗24h后上升较对照组更明显；对照组并发症发生率明显高于观察组.结论 高频振荡通气是一种较安全的机械通气方式,对于重症呼吸衰竭的新生儿应尽早应用.

Objective To discuss the clinical effect of high-frequency oscillatory ventilation in treatment of infants with severe respiratory failure. Methods 85 patients with severe respiratory failure were selected in NICU from January 2010 to January 2013,all patients were randomly divided into control group（42 cases）and observation group（43 cases）, and two groups were respectively given conventional mechanical ventilation and high-frequency oscillatory ventilation treatment. Results The treatment time of control group was significantly longer than the observation group. After 6, 12, 24 h treatment, FiO2 and PaCO2 of the observation group decreased more significantly compared with the control group, after 24 hours treatment a/APO： increased more obviously compared with the control group. Conclusion High frequency oscillatory ventilation is a relatively safe mechanical ventilation for severe respiratory failure, the newborn should be applied as soon as possible.