二甲双胍治疗抗精神病药物所致闭经泌乳综合征的疗效观察

Effect of metformin on antipsychotic drug-induced galactorrhea-amenorrhea syndrome

目的观察二甲双胍治疗药源性闭经泌乳综合征(GAS)的临床疗效。方法选择本院116例GAS患者,在服用抗精神病药物的同时,给予二甲双胍治疗。在治疗前,治疗第4、8周时测定催乳素水平,进行疗效评定。结果全部患者痊愈40例,显效42例,有效24例,无效10例,总有效率为91.4%。治疗后催乳素水平下降明显,与治疗前比较,差异有统计学意义(P<0.01)。结论二甲双胍治疗抗精神病药物所致GAS的疗效显著。

Objective To observe the clinical effect of metformin in treating antipsychotic drug-induced galactorrhea- amenorrhea syndrome （GAS）. Methods 116 patients with GAS in our hospital received antipsychotic drug-therapy,and combined with metformin.The efficacy was evaluated by determining prolactin level before treatment,4 and 8 weeks af- ter treatment. Results 40 cases were cured,42 cases were markedly effective,24 cases were effective,10 cases were in- valid, and the total effective rate was 91.4%. Further analysis showed that before and after treatment the differences of prolactin level were significant （P〈0.01）. Conclusion Effect of metformin for treatment of antipsychotic drug-induced GAS is satisfactory.