盐酸替罗非班治疗急性冠状动脉综合征的效果观察

Effect observatin of tirofiban in treatment of acute coronary syndrome

目的 探讨盐酸替罗非班治疗急性冠状动脉综合征（ACS）的临床效果.方法 选取2012年1月～2013年1月本院收治的ACS患者130例,将其随机分为观察组和对照组各65例,对照组采用常规治疗（阿司匹林＋氯吡格雷）,观察组在对照组治疗的基础上给予盐酸替罗非班.比较两组患者治疗后2d内出血事件发生率及术后30 d主要不良心血管事件发生率.结果 治疗后2d,观察组无出血及轻度出血发生率与对照组比较,差异均有统计学意义（P＜0.05）;治疗后30 d,观察组心肌梗死及顽固心肌缺血发生率均低于对照组（P＜0.05）.结论 在常规治疗的基础上合用盐酸替罗非班治疗ACS是安全有效的.

Objective To investigate the clinical effect of tirofiban in the treatment of acute coronary syndrome（ACS）. Methods 130 patients with ACS selected in our hospital from January 2012 to January 2013 were randomly divided into observation group and control group,with 65 cases in each group,the control group was treated with conventional therapy （aspirin plus clopidogrel）,the observation group was given tirofiban on the basis of control group treatment.The bleeding event rate in 2 days and major cardiovascular events rate in postoperative 30 days of the two groups were recorded. Results After the 2 days treatment,the differences of the no bleeding and minor bleeding between the two groups were all statistically signiticant（P〈0.05）;30 days after the treatment,recurrent myocardial infarction and refracto- ry ischemia of the observation group were lower than that of the control group （P〈0.05）. Conclusion The treatment of ACS with tirofiban on the basis of conventional treatment is safe and effective.