坎地沙坦酯治疗轻、中度原发性高血压的临床研究

Clinical effect of candesartan cilexetil in the treatment of essential hypertension

目的观察坎地沙坦酯片治疗轻、中度原发性高血压的疗效。方法采用随机、单盲、平行对照试验。将110例原发性高血压患者随机分为治疗组和对照组各55例。治疗组给予坎地沙坦酯片8mg口服治疗,1次/d;对照组给予缬沙坦片80mg口服治疗,1次/d。服用2周后,若舒张压≥12kPa则剂量加倍,疗程为8周。比较2组的降压疗效、幅度及心率变化。结果治疗组总有效率为90.9%,对照组的87.3%,2组比较无显著差异(P>0.05)。2组治疗前、后血压降低幅度均有显著差异(P<0.01),但2组间比较无显著差异(P>0.05)。2组治疗前、后心率均无明显变化,组间比较无显著差异(P>0.05)。结论坎地沙坦酯片治疗轻、中度原发性高血压疗效确切,不良反应少,患者耐受性良好,临床应用安全。

Objective To study the clinical effect of candesartan cilexetil in the treatment of mild to moderate essential hypertension. Methods In a randomized, single blind, parallel controlled trial, 110 cases of patients with mild and moderate essential hypertension were randomly divided into treatment group and control group. The treatment group received eandesartan cilexetil 8 mg oral 1/d,while the control group was given valsartan 80 mg oral once daily for 8 weeks. Dose doubling was carried out for those with diastolic blood pressure/〉 12 kPa after 2 wk treatment. The antihypertensive effect and changes in am- plitude and heart rate were compared between the 2 groups. Results The total effect rate of the treatment group was 90.9% and the control group was 87.3 % , so there was no significant difference between 2 groups （ P 〉 0.05 ）. A significant reduction of blood pressure （SBP or DBP） was achieved in both groups （P 〈 0.01 ） , but there was no significant difference between 2 groups （P 〉 0.05 ）. Before and after treatment, there was no significant changein heart rate, and there was no significant difference between 2 groups （ P 〉 0.05 ）. Conclusion Candesartan cilexetil once daily is effective, safe and well tolerated in mild to moderate hypertension patients,which is worthy of clinical application.