非那雄胺隔日给药治疗良性前列腺增生的效果观察

Effect observation of finasteride alternate-day dosing in benign prostatic hyperplasia

目的观察非那雄胺隔日给药治疗良性前列腺增生的临床效果。方法将100例良性前列腺增生患者随机分为观察组和对照组各50例。观察组给予非那雄胺5mg口服,每2天1次;对照组给予非那雄胺5mg口服,每天1次,比较2组临床疗效、国际前列腺症状评分(IPSS)、最大尿流率、前列腺体积、生活质量评分(QOL)及不良反应。结果观察组有效率稍低于对照组,但差异无统计学意义(P>0.05)。治疗6个月后,2组IPSS评分、最大尿流率、前列腺体积和QOL评分均优于治疗前,差异均有统计学意义(P<0.05);观察组稍高于对照组,但差异无统计学意义(P>0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论非那雄胺隔日给药治疗良性前列腺增生,效果较为满意,值得推广应用。

Objective To observe the effieaey of finasteride alternate-day dosing in benign prostatic hyperplasia. Methods 100 eases patients with benign prostatic hyperplasia were randomly divided into observation group and control group ,each of 50 eases. Observation group was treated by finasteride ,Stag,oral ,once every two days. Control group was treated by finasteride,5mg, oral, once a day. Compared the elinieal efficacy, international prostate symptom score （IPSS）, maximum flow rate, prostate volume, quality of life （QOL） score and adverse reaction of two group. Results The effieieney of observa- tion group was higher than that of control group, but the difference was no statistically significant（ P 〉 0.05 ）. After 6 months of treatment, the IPSS, maximum flow rate, prostate volume, QOL of two groups were higher than that before treatment, the differ- enee was statistically significant （ P 〈 0.05 ）. After 6 months of treatment, the IPSS, maximum flow rate, prostate volume, QOL of observation group was higher than that of control group, but the differenee was no statistically signifieant（ P 〉 0.05 ）. The inci- dence of adverse reactions of 2 groups was no statistically significant （ P 〉 0.05 ）. Conclusion Finasteride alternate-day do- sing in benign prostatic hyperplasia has an good efficacy. Worthy of clinical application.