耐药细菌蛋白质的分泌——新抗攻击的靶点

Protein secretion from drug-resistant bacteriaa suitable target for new antibiotics

几十年来 ,由于抗生素的大量使用 ,导致了细菌对很多药物的抗药性 .为了克服细菌的抗药性问题 ,需要用新的思路去发掘新的抗生素 ,包括发掘细菌细胞中存在的抗生素作用的新靶点 .蛋白质的分泌过程对于细菌是生死攸关的 ,它可能成为新药物的适合靶点 .

This paper reviewed the pathways of bacterial protein secretion and discussed the targets of pathogenic bacteria for antibiotics.Inhibition of protein secretion could lead to the growth decline,morphological alteration,and reduction of bacterial virulence,as well as the deprivation of their drug resistant.It was concluded that protein secretion could be a suitable target for new antibiotic agents.