我院抗菌药不良反应/事件报告相关因素分析

Analysis of Related Factors of Antibacterial Drug ADR/ADE Reports in our Hospital

目的：分析我院抗茵药不良反应/事件（ADR/ADE）报告,了解我院抗菌药ADR/ADE发生的特点,为临床合理用药提供参考。方法：对我院2006年1月~2012年12月收集到的324例抗菌药ADR/ADE报告,从患者情况、不良反应的临床表现、给药途径、抗茵药的种类及因果关系的评价等方面进行回顾性统计分析。结果：324例抗菌药不良反应/事件报告中,女性多于男性;50~87岁的患者所占比例最高;头孢菌素类居首位（47.53%）;其次为喹诺酮类（29.01%）;给药途径以静滴所占比例最高（90.12%）;累及的系统及器官前三位是皮肤及其附件、消化系统、中枢神经系统。结论：加强抗茵药分级管理,严格掌握用药指征,减少或者避免不良反应/事件的发生。

Objective：To analyze reports of antibacterial adverse drug reaction/event（ADR/ADE） reports to un- derstand characteristics and rules of antibiotic ADR/ADE in our hospital and provide the reference for clinical rational drug use. Methods ：324 cases of antibacterial drug ADR/ADE reports were collected inour hospital between January 2006 and December 2012 to statistically analyze the clinical manifestations of adverse reactions, route of administration, antibacterial drug types and retrospective causal evaluation. Results：324 antibacterial drugs ADR reports were more related to women than men ; patients from 50 to 87 years old accounted for the highest percent. As for the drug varieties, cephalosporins took the leading position, accounting for 47.53% and were followed by fluoroquinolones, accounting for 29.01%. And as for the administration route, intravenous drip had the largest share in 292 cases, accounting for 90.12%. The front 3 systems and organs involved in by antibacterial adverse drug reactions were mainly the skin and its accessories, the digestive system and the central nervous system. Conclusion：The antibacterial drug classification management should be strengthened and drug indications, strictly controlled to reduce or avoid the occurrence of adverse reactions.