摘要
目的:评价窄谱中波紫外线(NB-UVB)联合丙酸氯倍他索乳膏治疗轻度寻常型银屑病的疗效和安全性。方法:96例寻常型银屑病患者分为治疗组、对照1组和对照2组,各32例,治疗组患者给予NB-UVB光疗,3次/周,外用丙酸氯倍他索乳膏,2次/d,疗程6周;对照1组患者外用丙酸氯倍他索乳膏,2次/d,疗程6周;对照2组患者给予NB-UVB光疗,3次/周,疗程6周。结果:治疗组患者治疗后有效率为81.25%;对照1组患者治疗后有效率为56.25%;对照2组患者治疗后总有效率为53.13%。治疗组与对照1组、对照2组疗效比较差异均有显著的统计学意义(χ2=4.654 5,P=0.031 0;χ2=5.740 9,P=0.0166);对照1组与对照2组疗效比较差异无显著的统计学意义(χ2=0.0631,P=0.801 7)。三组患者均无明显不良反应。结论:NB-UVB联合外用丙酸氯倍他索乳膏治疗轻度寻常型银屑病是安全的、有效的。
Objective To observe the clinical effect and safety of NB - UVB combined with clobetasol propionate cream in treatment of mild psoriasis vulgaris. Method Nity - six cases with mild psoriasis vulgaris were divided into treatment group, control group 1 and control group 2 randomly. Thirty - two patients in the treatment group were treated with NB - UVB 3 times weekly and topically treated with clobe tasol propionate cream twice every day for 6 weeks. Thirty - two patients in the control group 1 were topically treated with clobetasol propio hate cream twice every day for 6 weeks. Thirty - two patients in the control group 2 were treated with NB - UVB 3 times weekly for 6 weeks. Results The effective rates were 81.25% ,56.25% and 53.13% in the treatment group, control groupl and control group2, respectively. The effective rate of treatment group was statistically significant higher than that of the control groupl and control group 2 (X2 = 4. 654 5,P = O. 031 0 ;X2 = 5.7409,P = 0. 016 6). The effective rate of control group 1 was no statistically significant higher than that of control group 2(X2 =0. 063 1 ,P =0. 8017). No marked side effects were observed in 3 group. Conclusion Our results showed that NB - UVB combined with clobetasol propionate cream is efficacy and safety in the treatment of psoriasis vulgaris.
出处
《吉林医学》
CAS
2013年第28期5778-5779,共2页
Jilin Medical Journal