抗环瓜氨酸肽抗体定量检测在老年性类风湿关节炎的诊断价值

Diagnostic value of quantitative detection of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis of senile

目的:探讨抗环瓜氨酸肽(ccp)抗体的定量检测在老年性类风湿关节炎(RA)中的诊断价值,为临床诊断提供依据。方法:收集68例RA患者、50例健康人的血清,检测抗-ccp抗体、RF、hCRP、ESR、Hb、PLT等数据,分析其内在联系。结果:对于68例老年性RA患者,当RF值比较低甚至阴性时,也能检出抗ccp抗体;所检出的抗ccp抗体、RF、hCRP、ESR、Hb、PLT数据在两组之间差异有统计学意义(P<0.05);抗ccp抗体水平与RF、hCRP、ESR、PLT呈正相关关系,与Hb呈负相关关系。结论:对于老年性RA患者的诊断,与RF相比,抗ccp抗体具有灵敏度高,特异性好的特点,可用于早期诊断。抗ccp抗体能反映RA的疾病活动情况,与病情发展密切相关。

Objective To explore the diagnostic value of quantitative detection of anti - cyclic citndlinated peptide antibody in patients with rheumatoid arthritis of senile ,and to provide a basis for clinical diagnosis. Method We collected serum of 68 patients with RA and 50 healthy human, tested data of anti -ccp, hCRP, ESR, Hb, Pit, analyzed the intrinsic link. Results In 68 cases of senile patients with RA, when the RF value was relatively low or even negative,it could also be detectable antibody;the detected data of anti -ccp.RF.hCRP.ESR. Hb.PLT, had significant difference between these two groups （P 〈 0. 05 ） ;Anti -ccp levels were positively correlated with RF.hCRP.ESR, PLT relationship, negative correlation with Hb relationship. Conclusion The diagnosis of senile patients with RA, compared with RF, anti - ccp has the advantages of high sensitivity, good specificity characteristics, so it can be used for early diagnosis. Anti -ccp can reflect the disease activity of RA,and closely related with disease development.