不同体质量指数的糖尿病患者使用预混胰岛素治疗后疗效及体重变化的观察

Efficacy of the treatment of premixed insulin in diabetics with different body weight index

目的:探讨不同体重指数的2型糖尿病患者在口服降糖药继发失效后,加用预混胰岛素治疗3个月后的疗效及体重变化。方法:选择口服降糖药失效的2型糖尿病患者共50例,按体重指数分为A组(BMI<25 kg/m2)和B组(BMI≥25 kg/m2)各25例,停用口服药物,三餐前加用门冬胰岛素30注射液皮下注射(商品名:诺和锐30)治疗3个月后,分别比较两组治疗前后空腹血糖、餐后2 h血糖、糖化血红蛋白、体重、血脂变化。结果:两组的空腹血糖、餐后2 h血糖、糖化血红蛋白均较治疗前明显下降,差异有统计学意义(P<0.01),A组BMI有轻度升高(P>0.05),而B组BMI未见明显改变。结论:对于不同体质量指数的2型糖尿病患者在口服降糖药继发失效后,加用新型预混胰岛素强化治疗,均有明确的疗效,且无明显体重增加的不良反应。

Objective To investigate the therapeutic effect of premixed insulin on the patients of type 2 diabetes with different body mass index （BMI） and secondary inefficiency of oral blood glucose lowering drugs. Method Fifty cases of type 2 diabetes with secondary inefficiency of oral blood glucose lowering drugs in 2011 were selected from our hospital. All the patients were divided into A group （ BMI 〈 25 kg/m2 ,25 cases） and B group （ BMI~〉25 kg/m2 ,25 cases）. After the treatment of subcutaneous injection with Insulin Aspart 30 （ no- vorapid 30 ） for three months, the changes of fasting serum glucose,2- hours postprandial blood sugar, glycosylated hemoglobin, body weight and blood fat were observed pre and post treatment. Results The fasting serum glucose,2 -hours postprandial blood sugar and glyco- sylated hemoglobin were significantly decreased in both groups after treatment （ P 〈 0. 01 ）. No significant changes of blood fat and BMI were observed in both groups. Conclusion The intensification therapy with premixed insulin is a safe and effective treatment for type 2 dia- betes with secondary inefficiency of oral blood glucose lowering drugs.