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组织工程心脏瓣膜构建的研究新进展 被引量：4

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摘要 在全球范围内每年约280 000个瓣膜置换术需进行[1],并且逐年增长,有研究预测到2050年需瓣膜置换术的人数将达850 000[2].我国每年也有近10万例患者接受瓣膜置换术,机械瓣膜和生物瓣膜在瓣膜置换术中的使用数量相当.然而目前的瓣膜假体存在许多问题：机械瓣有感染和血栓栓塞并发症的发生,为了防止血栓形成,需要终身抗凝治疗（如华法林）,由此而造成的出血发生率大大增加;生物瓣寿命只有10~15年,而且瓣膜开裂、瓣膜变性、瓣膜钙化等一系列问题还没有十分有效的预防措施;并且由于机械瓣和生物瓣再生、成长能力及耐用性的不足,尤其在儿童和年轻人中应用受到限制.为克服目前假体瓣膜在临床上的局限性,组织工程心脏瓣膜（tissue engineered heart valve,TEHV）应运而生.TEHV因其优良的组织相容性、耐久性及可生长性,不良反应小,具有非常大的临床应用潜能.现就TEHV的支架材料改性、种子细胞、支架材料与种子细胞的相互作用、生物反应器、临床研究以及微创TEHV植入等方面作如下综述.
作者 聂彬恩 胡时栋 周建良
机构地区 南昌大学第二附属医院心胸外科
出处 《广东医学》 CAS CSCD 北大核心 2013年第17期2721-2724,共4页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:81260047)
关键词 组织工程心脏瓣膜 瓣膜置换术 血栓栓塞并发症 生物瓣膜 机械瓣膜 临床应用 支架材料 TEHV
分类号 R318.11 [医药卫生—生物医学工程]
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参考文献25

  • 1PIBAROT P, DUMESNIL J G. Prosthetic heart valves: selection of the optimal prosthesis and long - term management [ J ]. Circu- lation, 2009, 119 (7) : 1034 - 1048.
  • 2FILOVA E, STRAKA F, MIREJOVSKY T, et al. Tissue -engi- neered heart valves [ J ]. Physiol Res, 2009, 58 ( Suppl 2) : S141 - S158.
  • 3DE VLAMING A, SAULS K, HAJDU Z, et al. Atrioventricular valve development: new perspectives on an old theme [ J ]. Diffe- rentiation, 2012, 84( 1 ) : 103 - 107.
  • 4STANKUNAS K, MA G K, KUHNERT F J, et al. VEGF signa- ling has distinct spatiotemporal roles during heart valve develop- ment[J]. Dev Biol, 2010, 347(2) : 325 -336.
  • 5COMBS M D, YUTZEY K E. Heart valve development regulatory networks in development and disease[J]. Circ Res, 2009, 105 (5) : 408 -421.
  • 6WIRRIG E E, YUTZEY K E. Transcriptional regulation of heart valve development and disease[ J]. Cardiovasc Pathol, 2011, 20 (3) : 162 -167.
  • 7GANDAGLIA A, BAGNO A, NASO F, et al. Cells, scaffolds and bioreactors for tissue - engineered heart valves: a journey from basic concepts to contemporary developmental innovations[J]. Eur J Cardiothorac Surg, 2011, 39(4) : 523 -526.
  • 8GERSON C J, ELKINS R C, GOLDSTEIN S, et al. Structural in- tegrity of collagen and elastin in SynerGraft & decellularized -cryopreserved human heart valves [ J ]. Cryobiology, 2012, 64 (1) : 38 -42.
  • 9BROWN J W, ELKINS R C, CLARKE D R, et al. Performance of the CryoValve SG human decellularized pulmonary valve in 342 patients relative to the conventional CryoValve at a mean follow - up of four years[ J]. J Thorac Cardiovasc Surg, 2010, 139 (2) : 339 - 348.
  • 10MASOUMI N, JEAN A, ZUGATES J T, et al. Laser microfabri- cated poly (glycerol sebacate) scaffolds for heart valve tissue engi- neering[J]. J Biomed Mater Res A, 2013, 101A(1) : 104 - 114.

二级参考文献2

共引文献1

同被引文献86

  • 1Weber A,Noureddine H,Englberger L. Ten-year comparison of pericardial tissue valves versus mechanical prostheses for aortic valve replacement in patients younger than 60 years of age[J].{H}Journal of Thoracic and Cardiovascular Surgery,2012,(05):1075-1083.
  • 2Rippel RA,Ghanbari H,Seifalian AM. Tissue-engineered heart valve:future of cardiac surgery[J].{H}WORLD Journal OF SURGERY,2012,(07):1581-1591.
  • 3Butcher JT,Nerem RM. Valvular endothelial cells and the mechanoregulation of valvular pathology[J].{H}Philosophical Transactions of the Royal Society of London Series B:Biological Sciences,2007,(1484):1445-1457.
  • 4Li S,Henry JJ. Nonthrombogenic approaches to cardiovascular bioengineering[J].{H}Annual Review of Biomedical Engineering,2011.451-475.
  • 5Schoen FJ. Evolving concepts of cardiac valve dynamics:the continuum of development,functional structure,pathobiology,and tissue engineering[J].{H}CIRCULATION,2008,(18):1864-1880.
  • 6Butcher JT,Mahler GJ,Hockaday LA. Aortic valve disease and treatment:the need for natural y engineered solutions[J].{H}Advanced Drug Delivery Reviews,2011,(4-5):242-268.
  • 7Riem VP,Kluin J,Sluijter JP. Environmental regulation of valvulogenesis:implications for tissue engineering[J].{H}European Journal of Cardio-thoracic Surgery,2011,(01):8-17.
  • 8Xu S,Grande-Al en KJ. The role of cellbiology and leaflet remodeling in the progression of heart valve disease[J].Methodist Debakey Cardiovasc J,2010,(01):2-7.
  • 9Schoen FJ. Evolving concepts of cardiac valve dynamics:the continuum of development,functional structure,pathobiology,and tissue engineering[J].{H}CIRCULATION,2008,(18):1864-1880.
  • 10Steinhoff G,Stock U,Karim N. Tissue engineering of pulmonary heart valves on al ogenic acellular matrix conduits:in vivo restoration of valve tissue[J].{H}CIRCULATION,2000,(19 Suppl 3):I50-I55.

引证文献4

二级引证文献13

广东医学
2013年 第17期

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