期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

氯胺酮在改良性电抽搐治疗难治性抑郁症中的应用 被引量：7

下载PDF
导出
摘要 目的 探讨以氯胺酮为麻醉剂的改良性电抽搐治疗（MECT）治疗难治性抑郁症的临床疗效及安全性.方法 60例难治性抑郁症患者随机分为两组,氯胺酮组（30例）使用氯胺酮作为麻醉剂进行MECT治疗;丙泊酚组（30例）使用丙泊酚作为麻醉剂进行MECT治疗.所有入组患者在MECT治疗前及治疗1~8次完成汉密尔顿抑郁量表（HAMD）、临床大体评定量表（GAS）及不良反应量表（TESS）评定.结果 两组在治疗结束后HAMD总分值均有明显下降,氯胺酮组在治疗第1次开始起效,丙泊酚组在治疗第3次开始起效;治疗第8次,氯胺酮组痊愈率为80.0%,明显高于丙泊酚组（23.3%）.而两组TESS分值差异无统计学意义（P〈0.05）.结论 氯胺酮MECT治疗难治性抑郁症是安全、有效的,且起效迅速.
作者 黄雄 何红波 张春平 王志杰 王达平 江妙玲 李启荣 蓝晓嫦 段炼 张敏玲 古智文 李莎
机构地区 广东省广州市精神病医院精神科
出处 《广东医学》 CAS CSCD 北大核心 2013年第18期2855-2858,共4页 Guangdong Medical Journal
基金 国家临床重点专科第一批院内项目(编号:201201002)
关键词 改良性电抽搐治疗 难治性抑郁症 氯胺酮
分类号 R749.4 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献13

  • 1黄雄,马静山,陈妙珍.改良性电抽搐治疗难治性抑郁症的效果[J].广东医学,2006,27(10):1521-1523. 被引量：2
  • 2NEMEROFF C B. Prevalence and management of treatment - resistant depression[J]. J Clin Psychiatry, 2007, 68(Suppl 8) : 17 -25.
  • 3LO0 C K, KAILL A, PATON P, et al. The difficult - to - treat electroconvulsive therapy patient - Strategies for augmenting out-comes[J]. JAffect Disord, 2010, 124(3): 219-227.
  • 4HUSAIN M M, RUSH A J, FINK M, et al. Speed of response and remission in major depressive disorder with acute electroconvulsive therapy (ECT) : a Consortium for Research in ECT (CORE) re- port[J]. J Clin Psychiatry, 2004, 65(4) : 485 -491.
  • 5AUTRY A E, ADACHI M, NOSYREVA E, et al. NMDA recep- tor blockade at rest triggers rapid behavioural antidepressant re- sponses[J]. Nature, 2011,475(7354): 91 -95.
  • 6LOO C B, SIMPSON B, MACPHERSON R. Augmentation strategies in electroconvulsive therapy[J]. J ECT, 2010, 26(3) : 202 -207.
  • 7ZARATE C A Jr, MATHEWS D, IBRAHIM L, et al. A random- ized trial of an N - methyl - D - aspartate antagonist in treatment - resistant major depression [ J]. Arch Gen Psychiatry, 2006, 63 (8) : 856 - 864.
  • 8OKAMOTO N, NAKAI T, SAKAMOTO K, et al. Rapid antide- pressant effect of ketamine anesthesia during electroconvulsivc ther- apy of treatment - resistant depression: comparing ketamine and propofol anesthesia[ J ]. J ECT, 2010, 26 (3) : 223 - 227.
  • 9DIAZGRANADOS N, IBRAHIM L, BRUTSCHE N E, et al. A randomized add - on trial of an N - methyl - D - aspartate antago- nist in treatment -resistant bipolar depression[ J]. Arch Gen Psy- chiatry, 2010, 67(8): 793 -802.
  • 10PRICE R B, NOCK M K, CHARNEY D S, et al. Effects of intra- venous ketamine on explicit and implicit measures of suicidality in treatment - resistant depression [ J ]. Biol Psychiatry, 2009, 66 (5) : 522 -526.

二级参考文献6

  • 1朱海兵,余金龙,郑洪波.米氮平治疗难治性抑郁症的临床对照研究[J].上海精神医学,2003,15(6):355-357. 被引量：14
  • 2李霞,陆峥,蔡军,陈静,熊祥玉,姚培芬,郭珍.难治性抑郁症的临床特征[J].中国新药与临床杂志,2005,24(8):627-629. 被引量：15
  • 3FOLKERT H W,MICHAEL N,TOLL R.Electroconvulsive therapy vs.paroxetine in treament-resistant depression-a randomized study[J].Acta Psychiatr Scand,1997,96:334-342.
  • 4WALTER W,ARIEJAN L,PAUL G H et al.Effect of antidepressant medication resistance on short-term response to electroconvusivetherapy[J].J Clin Psychopharmacology,2004,24:400-403.
  • 5HUSAIN S S,KEVAN I M,LINNELL R,et at.Electroconvulsive therapy in depressive illness that has not responded to drug treatment[J].2004,83(2/3):121-124.
  • 6喻东山.难治性抑郁症[J].山东精神医学,2003,16(1):61-63. 被引量：7

共引文献1

同被引文献40

  • 1宋志文,蔡理荣,李耀东,黄能达.无抽搐电休克治疗对抑郁症的疗效及记忆影响的研究[J].神经疾病与精神卫生,2005,5(6):424-426. 被引量：26
  • 2KESSLER R C,BERGLUND P, DEMLER 0,et al. The epidemi-ology of major depressive disorder : results from the National Co -morbidity Survey Replication ( NCS - R) [ J]. JAMA, 2003, 289(23): 3095 -3105.
  • 3KRISHNAN V,NESTLER E J. The molecular neurobiology of de-pression [J]. Nature, 2008, 455(16) : 894 — 902.
  • 4DILIP V J. Diagnostic and Statistical Manual of Mental DisordersFifth Edition[ M]. Washington: American Psychiatric Publishing,2013: 155 -187.
  • 5TRIVEDI M H, RUSH A J, WISNIEWSKI S R, et al. Evaluationof outcomes with citalopram for depression using measurement -based care in STAR . D: implications for clinical practice [ J ].Am J Psychiatry, 2006, 163(1) : 28 -40.
  • 6RUSH A J,TRIVEDI M H, STEWART J W, et al. Combiningmedications to enhance depression outcomes ( CO - MED) : acuteand long — term outcome of a single - blind randomized study [ J].Am J Psychiatry, 2011,168(7) ; 689 -701.
  • 7LOO C K, KAILL A, PATON P,et al. The difficult - to - treatelectroconvulsive therapy patient - strategies for augmenting out-comes[ J]. J Affect Disorder, 2010, 124(3) : 219 -227.
  • 8BERMAN R M, CAPPIELLO A, ANAND A, et al. Antidepres-sant effects of ketamine in depressed patients [ J ]. Biol Psychiatry,2000, 47(4) : 351 -354.
  • 9OKAMOTO N, NAKAI T,SAKAMOTO K, et al. Rapid antide-pressant effect of ketamine anesthesia during electroconvutsive ther-apy of treatment - resistant depression comparing ketamine andpropofol anesthesia[J]. J ECT, 2010,26(3) : 223 -227.
  • 10AUTRY A E,ADACHI M,NOSYREVA E, et al. NMDA recep-tor blockade at rest triggers rapid behavioral antidepressant respon-ses[J]. Nature, 2011, 475(15) : 91 -95.

引证文献7

二级引证文献52

广东医学
2013年 第18期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部