肺动脉高压与右心室重构的关系

The Relationship Between Pulmonary Arterial Hypertension and Right Ventricular Remodeling

肺动脉高压是以肺小动脉的收缩、内膜增生和重构为主要特征的一种疾病。肺小动脉的收缩和重构导致肺血管阻力进行性增加,右心室后负荷加重,将导致右心室重构,最终引起右心衰竭,甚至死亡。目前,左心室重构研究较多,而右心室重构研究较少,而且肺动脉高压时右心室重构的发生机制尚不明确。现就肺动脉高压与右心室重构的发生机制及其两者之间的关系作一综述。

Pulmonary arterial hypertension （PAH） is a disease characterized by changes in small pulmonary arteries including contraction, intimal hyperplasia and remodeling. The contraction and remodeling will cause increase in pulmonary vascular resistance and right ventricular afterload, then resulting right heart failure and even death. Currently, the researches on ventricular remodeling focus more on the left ventricle than the right ventricle, with the mechanisms in right ventricular remodeling in PAH remaining unclear. This review is about the mechanisms of right ventricular remodeling in PAH and the relationship between PAH and fight ventricular remodeling.