摘要
目的:建立快速、准确、高灵敏度的中成药中非法添加3种肾上腺皮质激素的检测方法。方法:采用超高效液相色谱-质谱联用法,离子源为ESI源,负离子检测,对抗风湿类中成药中非法添加的3种肾上腺皮质激素醋酸泼尼松、地塞米松、氢化可的松进行定性和定量检测。结果:11种受试制剂中1种检测到掺有醋酸泼尼松。结论:此方法选择性强、灵敏度高,可作为快速分析中成药中非法添加醋酸泼尼松、地塞米松及氢化可的松的有效检测方法。
Objective ： To establish a quick, accurate and sensitive method for the analysis of three illegally-added adrenal cortical hormones in anti-rheumatism Chinese patent drugs by UPLC/MS/MS. Method： A UPLC/MS/MS method was used. Electrospay ioni- zation （ESI） source was applied and operated in negative ion modes. The qualitative and quantitative method of the three illegally-add- ed adrenal cortical hormones in anti-rheumatism Chinese patent drugs were candied out. Result： Prednisone acetate was found in one formula among the eleven tested samples. Conclusion： The method is selective and sensitive, and can be used to detect the three ille- gally-added adrenal cortical hormones in anti-rheumatism Chinese patent drugs.
出处
《中国药师》
CAS
2013年第9期1296-1298,共3页
China Pharmacist
基金
国家科技支撑计划项目(编号:2006BA114B03-2)
云南省技术创新人才培养对象第九批项目(2009CI107)
