GRIM-19和STAT3在骨肉瘤中的表达及意义

EXPRESSION AND SIGNIFICANCE OF GRIM-19 AND STAT3 IN OSTEOSARCOMA

目的:观察骨肉瘤中GRIM-19与STAT3的表达情况,探讨二者与骨肉瘤临床病理特征的关系及骨肉瘤二者表达的相关性。方法:采用免疫组织化学染色SP法检测35例骨肉瘤和14例骨软骨瘤GRIM-19与STAT3的表达情况。结果:骨肉瘤中STAT3的阳性表达率明显高于骨软骨瘤,GRIM-19的阳性表达率明显低于骨软骨瘤,差异均具有统计学意义(P<0.01);骨肉瘤中STAT3表达与Enneking分期、肺转移有关,GRIM-19表达与Enneking分期有关(P<0.05);骨肉瘤中STAT3表达与GRIM-19呈负相关(P<0.05)。结论:骨肉瘤组织中存在STAT3高表达和GRIM-19低表达共存现象,二者共同作用可能与骨肉瘤的发生、发展密切相关。

Objective：To investigate the relationships between gene associated with retinoid-interferon-induced mortality- 19 （GRIM- 19）, signal wansducem and activators of transcription 3 （STAI3） and clinical pathological characteristics of osteosarcoma, and their correlations in osteosarcoma by observing the expression of GRIM- 19 and STAT3 in osteosarcoma. Methods：SP immunohistochemical staining was used to detect the expression of GRIM-19 and STAT3 in 35 cases osteosarcoma and 14 cases osteochondroma. Results：The positive expression rate of STAT3 in osteosarcoma was obviously higher than that in osteochondmma, while the positive expression rate of GRIM-19 was obviously lower in osteosarcoma compared with osteochondroma （P〈 0.01）. In osteosarcoma the expression of STAT3 was associated with Enneking stage and pulmonary metastasis; the expression of GRIM-19 was associated with Enneking stage （P〈 0.05）. In osteosarcoma, the expression of STAI3 was negatively correlated with expression of GRIM-19 （P〈 0.05）. Conclusions： High expression of STAT3 and low expression of GRIM-19 coexist in osteosarcoma, which play important role in development ofosteosarcoma-