阿尔茨海默病患者药物治疗前后生活质量改善情况对比

Comparison of Improvement Situation of Life Quality before and after Medication in Patients with Alzheimer's Disease

目的探讨药物治疗对阿尔茨海默病(AD)患者生活质量的影响。方法对既往未服用过抗精神病药物、促认知药物的61例AD患者服用抗精神病药物和促认知药物,评定12周前后的生活质量,比较其生活质量改善情况。使用护士用住院患者观察量表(NOSIE)评定疗效。结果61例AD患者治疗后的社会能力、个人整洁、激惹、精神病性症状等4项因子分显著改善(P<0.05),社会兴趣、迟缓、抑郁等3项因子分改善不明显(P>0.05)。结论 AD患者在药物治疗后社会能力、个人整洁、激惹、精神病性症状等方面的生活质量有一定程度改善,在临床上可适当考虑使用促认知药物和小剂量的抗精神病药物。

Objective To explore the influence of medication on the life quality in the patients with Alzheimer＇s disease（AD）. Methods Sixty- one patients with AD without taking antipsychotic and cognitive- enhancing drugs took antipsychotic and cognitive- enhancing drugs and performed the evaluation on the life quality before treatment and after 12-week antipsychotic and cognitive-en- hancing medication. The improvement situations of life quality were compared. The Nurses＇ Observation Scale for Inpatient Evaluation （NOSIE） was used to assess the treatment efficacy. Results The 4 factor scores of the social ability, personal neatness, irritability and psychotic symptoms were significantly improved after medication（ P 〈 0. 05）;while the other 3 factor scores of the social interests, re- tardation and depression had no significant improvement after treatment（P 〉0.05）. Conclusion The social ability, personal neatness, ir- ritability and psychotic symptoms are improved to some extent after medication for AD patients. Cognitive- enhancing drugs and low- dose antipsychotie drugs can be appropriately considered to use in clinic.