孕产妇不规则抗体筛选结果分析

Analysis of maternal irregular antibody screening results

目的:研究孕产妇血清中不规则抗体检出的几率,探讨孕产妇不规则抗体对输血的影响以及对孕产妇不规则抗体检测的必要性。方法:对本地区17家医疗机构自2009-2012年3年的孕产妇3 654人次,用试管法、微柱凝胶法进行不规则抗体检查和确认,并与3783人次随机无偿献血者的血样进行对比。结果:孕产妇血清不规则抗体阳性率为1.18%,明显高于普通献血者的0.33%(P<0.05)。其中E抗体的阳性率为0.65%(24人次),C抗体的阳性率为0.33%(12人次),其他抗体的阳性率为0.18%(7人次),而普通献血者的相应抗体的阳性率分别为0.19%(7人次)、0.11%(4人次)、0.03%(3人次),均差异有统计学意义(均P<0.05)。结论:孕产妇作为受血者发生输血反应的几率比较高,输血时必须开展不规则抗体筛查,必要时做RhE、RhC同型输注。

Objective：To study the risk of maternal serum in irregular antibody detection,and explore the effect of irregular antibodies on maternal blood transfusion and the necessity of maternal irregular antibody detection. Method：Irregular antibody of maternal person-time from 3 65417 local medical institutions since 2009--2012 was tested and verified by tube method and microcolumn gel method,and the results were compared with that of 3 783 person time random blood donors. Result：The maternal serum irregular antibody positive rate of 1.18% was sig nificantly higher than that of normal blood donors,0.33%. The E antibody positive rate was 0.65% （24） ,C anti- body positive rate was 0. 33% （12 times） ,the positive rate of antibody to the other was 0.18% （7 times） ,the pos itive rate of antibodies and normal blood donors were 0. 19% （7 people）,0. 11% （4）,0.03% （3 people）. There were significant differences （P〈0. 05）. Conclusion： The incidence of transfusion reaction for pregnant women as recipients would be relatively high, so they must carry out the irregular antibody screening before blood transfu- sion. It is necessary to do the RhE and RhC homotypic infusion.