布地奈德与舒利迭序贯治疗慢性阻塞性肺疾病合并感染的疗效观察

Effect of budesonide combined with seretide on treatment of chronic obstructive pulmonary disease complicated with infections

目的观察在使用抗菌药物基础上,采用布地奈德雾化混悬液与舒利迭序贯性治疗慢性阻塞性肺疾病(COPD)急性发作合并感染的临床效果,为临床改进该病的治疗效果提供临床依据。方法选取2011年1月-2012年12月进行治疗的72例COPD急性发作期患者,将其随机分为观察组和对照组,各36例;观察组患者在常规抗菌药物抗感染治疗的基础上给予布地奈德雾化混悬液雾化吸入治疗3d后,序贯使用舒利迭;对照组患者在常规抗感染基础上采用沙丁胺醇雾化吸入治疗,用药1周后对患者肺功能指标和临床疗效进行比较分析。结果治疗1周后,观察组患者平均1秒用力呼气容积值和1秒用力呼气容积值与用力肺活量的比值改善明显优于对照组,其差异有统计学意义(P<0.05);对照组患者总有效率为83.30%,观察组患者总有效率为94.40%,两者相比差异有统计学意义(P<0.05),显示观察组临床疗效显著优于对照组。结论在使用抗菌药物基础上采用布地奈德雾化混悬液与舒利迭序贯治疗COPD发作合并感染,可迅速控制感染症状,改善肺功能,其疗效优于常规治疗方法,值得临床推广。

OBJECTIVE To investigate the effect of budesonide combined with seretide on treatment of chronic obstructive pulmonary disease （COPD） complicated with infections. METHODS Totally 72 cases of AECOPD patients from Jan 2011 to Dec 2012 in the hospital were selected and divided into the observation group （36 cases） and control group（36 cases）. Except to antibiotics, the observation group was treated with budesonide combined with seretide,while the control group only with albuterol treatment. Pulmonary function and clinical efficacy of the two groups were observed after one week. RESULTS One week after treatment, mean FEV1 value and FEV1 / FVC value improvement of the observation group patients were obviously superior to the control group （P^0.05）. The total effective rate was 94. 4% in the observation group and 83. 3~ in the control group, respectively,and the difference was significant （P〈0.05）. CONCLUSION The budesonide combined with seretide based on use of antibiotics can quickly control the symptoms of infections and improve lung function, and its curative effect is superior to that of conventional treatment, it is worthy to he promoted.