两种皮肤消毒剂对外科手术部位感染预防作用的荟萃分析

Meta-analysis of effects of two skin disinfectants on prevention of surgical site infections

目的比较术前氯己定和聚维酮碘皮肤消毒对外科手术部位感染发生率的影响，为有效选择消毒剂，减少手术部位感染发生率提供依据。方法对2012年3月前发表的关于氯己定与聚维酮碘消毒对外科手术部位感染发生率影响的文献进行荟萃分析，结果选取相对危险度（RR值）及其95％CI表示。结果共纳入8篇文献5633例患者，荟萃分析结果显示，聚维酮碘组外科手术部位感染发生率为9．29％，氯己定组为6．95％，氯己定消毒可降低外科手术部位感染的发生（RR=0．75，95％CI=0．63～0．89）。结论术前氯己定消毒比聚维酮碘消毒能更好预防外科手术部位感染发生。

OBJECTIVE To compare influence of skin disinfection with chlorhexidine and povidone-iodine on the incidence of surgical site infections so as to choose effective disinfectant and reduce the incidence of surgical site infections. METHODS A meta-analysis was performed for the articles about the influence of disinfection with chlorhexidine and povidone-iodine on the incidence of surgical site infections issued before Mar 2012, and the results were interpreted by using relative risk （RR） and 95% confidence intervals （CIs）. RESULTS A total of 8 articles were included in the study, with 5633 patients involved, the meta-analysis showed that the incidence rate of surgical site infections was 9.29 ~ in the povidone-iodine group, 6.95 ~ in the chlorhexidine group, and that the disinfection with chlorhexidine could reduce the incidence of surgical site infections （RR= O. 75, 95 MCI= O. 63 -0.89）. CONCLUSION The preoperative skin disinfection with chlorhexidine is superior to povidone-iodine in the prevention of surgical site infections.