氧氟沙星滴耳液用于急性化脓性中耳炎治疗的临床效果分析

Therapeutic effect of ofloxacin ear drops on treatment of acute otitis media

目的探讨氧氟沙星滴耳液用于急性化脓性中耳炎治疗的临床效果及安全性,为临床治疗提供参考依据。方法选取医院2005年1月-2011年12月收治急性化脓性中耳炎患者300例,采用随机数字表法分为对照组和氧氟沙星组,每组各150例;其中对照组患者采用氯霉素滴耳液治疗;氧氟沙星组采用氧氟沙星滴耳液治疗;比较两组患者临床改善总有效率、病原菌清除率、起效时间、听力改善程度及不良反应发生等。结果对照组与氧氟沙星组患者临床改善总有效率分别为72.7%、97.3%;氧氟沙星组患者临床改善总有效率明显高于对照组,组间比较差异有统计学意义(P<0.05);氧氟沙星组患者病菌清除率、起效时间及听力改善程度分别为96.7%、(6.4±1.1)d、(7.7±2.2)dB,对照组分别为78.0%、(9.2±2.4)d、(3.2±0.8)dB,组间比较差异有统计学意义(P<0.05);对照组与氧氟沙星组患者耳部刺痛发生率分别为4.0%、0.7%;耳部瘙痒发生率分别为8.0%、4.7%;氧氟沙星组患者耳部刺痛及耳部瘙痒发生率均明显低于对照组,组间比较差异有统计学意义(P<0.05)。结论相比于氯霉素滴耳液,氧氟沙星滴耳液用于急性化脓性中耳炎治疗能够有效改善临床症状,彻底清除病原菌,缩短病程,且不良反应发生风险低,具有临床推广使用价值。

OBJECTIVE To investigate the therapeutic effect and safety of ofloxacin ear drops on the treatment of acute otitis media so as to guide the clinical treatment. METHODS A total of 300 patients with acute otitis media were chosen in the period from Jan 2005 to Dec 2012 in the hospital and randomly divided into two groups including the control group （150 patients） with chloramphenicol ear drops treatment and the ofloxacin ear drops group （150 patients） with ofloxacin ear drops treatment; and the total effective rate of clinical improvement, clearance rate of pathogens, onset time, degree of hearing improvement, and incidence of adverse reactions were compared between the two groups. RESULTS The total effective rate of the clinical improvement of the ofloxacin ear drops group was 97.3 % , significantly higher than 72.70% of the control group, the difference between the two groups was significant （P〈0.05）. The clearance rate of pathogens, onset time and degree of hearing improvement of the ofloxacin ear drops group were respectively 96. 7~, （6. 4 ~ 1. 1） d, and （7. 7 -4- 2. 2） dB, and were respectively 78.0%, （9.2~2.4）d, and （3.2_--60.8）dB of the control group, the difference between the two groups was significant （P〈~0.05）. The incidence of ear tingling of the ofloxacin ear drops group was 0.7 ~/00, significantly lower than 4.0~ of the control group ; the incidence of ear itching of the ofloxacin ear drops group was 4.7 ~, significantly lower than 8.0% of the control group （P^0.05）. CONCLUSION Compared with chloramphenicol ear drops, the tofloxacin ear drops can efficiently improve clinical symptoms of the patients with acute otitis media, eradicate the pathogens, and shorten the illness course, with the incidence of adverse reactions low, it is worthy to be promoted.