沙棘籽油抗抑郁作用

Antidepressant Effect of Seabuckthorn Seed Oil

采用悬尾实验(TST)和强迫游泳实验(FST)观察沙棘籽油对小鼠不动时间的影响;采用慢性温和不可预知应激程序(CUMS)复制大鼠抑郁模型,观察沙棘籽油对大鼠体质量、糖水偏爱、行为活动等指标的影响,从而探讨沙棘籽油的抗抑郁作用,发现其新的功效。结果表明:沙棘籽油能明显减少小鼠悬尾实验和强迫游泳实验中的不动时间(P<0.05,P<0.01),对CUMS模型大鼠体质量、糖水偏爱、行为活动等指标均有不同程度的改善(P<0.05,P<0.01),表明沙棘籽油具有明显的抗抑郁作用。

The effect of seabuckthorn seed oil on the immobility time in mice was investigated by tail suspension test （TST） and forced swimming test （FST）. Body weight, sucrose preference and open-field activities were conducted on mice with depression induced by chronic unpredictable mild stress （CUMS） to explore the antidepressant effect of seabuckthorn seed oil. The results showed that administration of seabuckthorn seed oil was capable of reducing the immobility time in FST and TST while other indices such as body weight, sucrose preference, open-field activities were increased significantly （P 〈 0.05, 0.01）. These findings implicated that seabuckthorn seed oil might be a potential antidepressant for developing functional foods or drugs.