糖皮质激素在感染性疾病治疗中的应用

Application of glucocorticoids to infectious diseases

在感染性疾病治疗中,糖皮质激素的应用是一把双刃剑。对一般感染或轻症感染,原则上不使用糖皮质激素进行治疗。对于严重感染所致休克、多器官功能衰竭、某些特定治疗目标,糖皮质激素可改善其预后,减轻某些特定的损害。糖皮质激素常应用于手足口病危重症、各种重症病毒性肺炎、某些类型的结核病、布鲁菌病或流行性腮腺炎并发睾丸炎以及各种严重感染所致休克等的治疗中。糖皮质激素的使用中还应注意用药时机、剂量、疗程及其毒副反应。

The application of glucocorticoids is a double-edged sword in the treatment of infectious diseases. Glucocorticoid shouldn＇t be used in general or mild infections in principle. For shock, multiple system organ failure caused by serious infec- tions, or for a particular target, the use of glucocorticoids may improve the prognosis and reduce certain impairments. Glu- cocorticoids are commonly used in severe hand foot and mouth disease（ HFMD）, severe viral pneumonia, certain types of tu- berculosis, orchitis complicated with brucellosis or mumps, shock caused by a variety of severe infections and so on. The tim- ing of medication, dosage, course of treatment and side effects should be paid attention to.