术后辅助化疗对具有高危因素老年Ⅱ期结肠癌生存价值研究

Impact of postoperative adjuvant chemotherapy on survival of high-risk elderly patients with stage Ⅱ colon cancer

目的探讨术后辅助化疗对老年Ⅱ期具有高危因素的结肠癌患者生存期的影响。方法收集北京大学医学院附属肿瘤医院结直肠外科2006—2008年收治的46例年龄在65岁以上、Ⅱ期结肠癌患者的临床病理和随访资料,将术后辅助化疗和未化疗的患者分为2组,其中化疗组25例,未化疗组21例。采用Kaplan-Meier法计算生存率,并绘制生存曲线,生存曲线的比较采用Log-rank检验,显著性水准α=0.05。结果两组患者性别、肿瘤大小、术前癌胚抗原(CEA)水平、淋巴结数目、疾病构成差异无统计学意义(P>0.05),两组患者的3年生存率,化疗组83.2%,未化疗组72.6%。两组生存曲线显示,差异无统计学意义(P>0.05)。结论对Ⅱ期老年结肠癌术后辅助化疗的临床意义不明显,并没有显著提高老年患者的生存率。

Objective To explore the impact of postoperative adjuvant chemotherapy on survival of high-risk elderly patients with stage H colon cancer. Methods Clinical pathological and follow-up data of 46 patients aged over 65 years with stage Ⅱ colon cancer were collected this data was divided into chemotherapy group （n = 25 ） and non-chemotherapy group （n = 21 ）. Thc Kaplan-Meicr method was used to calculatc survival rate. Survival curves were drawn, and were then compared u- sing the Log-rank test. Results No significant differences wcre obscrved between the chemotherapy group and non-chemo- therapy group in gender,tumor size,preoperative CEA level, number of lymph nodes, and disease （ P 〉 0. 05 ）. The 3-year survival rates of the two groups were 83.2% in the chemotherapy group and 72. 6% in the chemotherapy group, respectively. The two sets of survival curves showed no significant difference （ P 〉 0. 05 ）. Conclusion Postoperative adjuvant chem-otherapy in elderly patients with stage Ⅱ colon cancer is of no marked clinical significance and does not significantly improve the survival of elderly patients.