摘要
[目的]旨在探索并优化出一条适合工业化生产N-甲基-N-异丙基胺基磺酰胺的工艺路线。[方法]氯磺酰异氰酸酯与甲酸水溶液反应得到氨基磺酰氯,然后与N-甲基-N-异丙基胺反应得到目标产物N-甲基-N-异丙基胺基磺酰胺。[结果]反应总收率为62.7%,产物与中间体经1H NMR、MS等进行了表征。[结论]该路线收率较高,操作简便,可作为工业生产路线。
[Aims] This article aims to explore and optimize a reasonable synthesis route of N-methyl-N-isopropyl sulfonamide on industrial scale. [Methods] Amino sulfonyl chloride was synthesized from chloriosulfonyl isocyanate and aqueous formic acid, then reacted with N-methy-N-isopropyl amine to get the target product. [Results] The total yield was 62.7%. The products and intermediates were determined by H NMR and MS and so on. [Conclusions] The yield is improved and the process is simplified, which can be used in industry.
出处
《农药》
CAS
CSCD
北大核心
2013年第10期721-722,725,共3页
Agrochemicals
