老年腹膜透析患者外周动脉疾病及其危险因素分析

Risk factors for peripheral artery disease in elderly patients on peritoneal dialysis

目的探讨老年腹膜透析患者外周动脉疾病(PAD)的发病率和危险因素。方法选择62例老年腹膜透析患者,分为PAD组19例,非PAD组43例。收集其临床、生化等资料,进行分析比较,采用多因素logistic分析PAD的危险因素。结果 PAD的总发病率为30.6%。与非PAD组比较,PAD组患者年龄偏大,透析龄明显延长,空腹血糖、糖化血红蛋白、C反应蛋白明显升高,舒张压、踝臂指数、白蛋白、残余肾总尿素清除率(Kt/V)比值明显降低(P<0.05,P<0.01)。多因素logistic分析显示,年龄(OR=1.150,P=0.043)、血清白蛋白水平(OR=1.485,P=0.040)、残余肾Kt/V比值(OR=1.725,P=0.016)为PAD的危险因素。结论老年腹膜透析患者PAD患病率较高,年龄、血清白蛋白水平、残余肾Kt/V比值为PAD的独立危险因素。

Objective To study the incidence of peripheral artery disease （PAD） and its risk factors in elderly patients on peritoneal dialysis （PD）. Methods Sixty-two elderly patients on PD were divided into PAD group （n=19） and non-PAD group （n=43）. Their clinical and biochemical data were compared and risk factors for PAD were analyzed by multivariate logistic analysis. Results The total incidence of PAD was 30. 6% in the patients. The age was older, the time of PD was longer, the serum levels of fasting blood glucose, HbAlc and CRP were significantly higher where as the diastolic blood pressure,ankle-buttock index,serum albumin level and residual renal Kt/V value were significantly lower in PAD group than in non-PAD group （P〈0.05 ,P〈0.01）. Logis- tic regression analysis showed that age （OR=1. 150, P = 0. 043）, serum albumin level （OR= 1. 485,P=0. 040） and residual renal Kt/V value （OR= 1. 725,P=0. 016） were the risk factors for PAD. Conclusion The incidence of PAD is high in elderly patients on PD. Age, serum albumin level and residual renal Kt/V value are the independent risk factors for PAD.