基于均匀设计的藜芦与白芍配伍的毒性研究

Uniform design research on the compatibility toxicity of veratridine and peony

目的:探讨藜芦与白芍配伍后的毒性变化规律,为"十八反"的深入研究提供依据。方法:本实验采用均匀设计结合动物急性毒性实验,以动物死亡率为观测指标进行急性毒性评价。结果:配伍后的毒性大小是由藜芦和白芍的比例、藜芦及白芍的用量综合所致,配伍后毒性以藜芦的毒性为主,死亡率随藜芦比例的增大呈现上升趋势,而随白芍用量的增加又下降。结论:基于本实验条件下,藜芦与白芍配伍后的毒性并未增加,此结果为临床合理用药提供参考依据。

Objective： To investigate the toxicity variation of veratridine combined with peony, and to provide the basis for in-depth study of the eighteen imcompatible pairs. Methods： In this subject, we used the uniform design combined with animal acute toxicity, and used the mortality rate as observation to evaluate acute toxicity of animal. Results： The toxicity of peony combined with veratridine was determined by three areas： the ratio of veratridine and peony, veratridine dosage and the amount of peony. The toxicity of veratrum-based was the main toxicity. The mortality ratio with the increased use of veratridine showed a upward trend, with the increased use of peony showed a downward trend. Conclusion： Based on the experimental conditions, the toxicity of veratridine combined with peony dose not increase, offer scientific basis for reasonable usage.