青藤碱治疗类风湿性关节炎的研究进展及展望

Progress and the prospect of Sinomenine to treat rheumatoid arthritis

类风湿性关节炎(RA)是一类以多关节为主的全身性难治性自身免疫性疾病。RA发病机制尚不明确,可能与免疫细胞活化与表达异常、细胞增殖与凋亡失衡、核因子κB异常活化以及基质金属蛋白酶表达下降等有关。中药青风藤及其主要有效成分为青藤碱(SIN)具有镇痛、抗炎、免疫抑制等多种药理作用,临床用于治疗RA疗效确切、安全、副作用少。文章在查阅大量国内外文献的基础上,对青藤碱在治疗RA的研究进展方面进行综述,旨在为以后的临床研究提供理论依据。

Rheumatoid arthritis （RA） is a polyarticular systemic refractory autoimmune disease. The pathogenesis of RA is not clear, and may be associated with the immunocytic disorder of activation and expression, cell disequilibrium of apoptosis and multiplication, abnormal activation of nuclear factor KB, and matrix metalloproteinases expression decreased and so on. Traditional Chinese medicine Caulis Siuomenii and its active ingredient sinomenine have multiple functions, including analgesia, anti-inflammation and immunosuppression, which is a new immunosuppressant with good efficacy and safety, fewer side effects on treatment of rheumatoid arthritis. This article overviews the progress of sinomenine treatment of rheumatoid arthritis based on a large number of domestic and foreign literatures, in order to provide a theoretical basis for future clinical studies.