基于医用电子鼻技术的表证患者气味识别分析

Identification and analysis of odor of patients with exterior syndrome based on medical electronic nose

目的:运用自主研发的医用电子鼻探讨表证患者口腔呼气的气味图谱特征及气味识别准确率。方法:选择表证青年患者150例和健康青年人200名,运用基于薄膜型气体传感器阵列技术的医用电子鼻(Nanofilm-Enose Medical001)采集口腔呼气的气味图谱,以响应曲线的振幅和上升斜率作为曲线特征,分析表证患者及其寒热病性的图谱特征,并进行判别分析。结果:表寒证和表热证患者的气味图谱响应曲线A、B、D、E、G、H的振幅和上升斜率均显著高于健康学生(P<0.01)。表热证患者的气味图谱响应曲线A、B、D、E、H的振幅和上升斜率均显著高于表寒证患者(P<0.05,P<0.01),表热证患者的气味图谱响应曲线G的振幅显著高于表寒证患者(P<0.01)。判别分析显示对健康青年人、表寒证青年患者、表热证青年患者口腔呼气的识别准确率分别为90.5%、86.5%、88.0%,对全部案例的识别准确率为89.1%。结论:表证青年患者口腔呼气的气味较健康青年人浓烈,且表热证青年患者气味变化较表寒证青年患者更明显,本医用电子鼻能够较为敏感和准确地辨识表证青年患者口腔呼气的气味特征及其寒热病性。医用电子鼻技术的发展可为中医嗅诊客观化研究提供手段和方法。

Objective： to explore the odor response pattern characteristics of oral breath of patients with exterior syndrome and accuracy rates of odor identification by medical electronic nose which was independent research and development. Methods： 150 young patients with exterior syndrome and 200 healthy young students were observed. Odor response patterns of oral breath were collected by the electronic nose （Nanofilm-Enose Medical001） based on a film of gas sensor array. The amplitude and rising slope of response curves were selected as curve characteristics to analyze pattern characteristics of exterior syndrome including exterior cold syndrome and exterior heat syndrome, and discriminant analysis was done. Results： In odor response patterns of patients with exterior cold syndrome and with exterior heat syndrome, the amplitudes and rising slopes of response curve A, B, D, E, G and H were significantly higher than those of healthy students （P〈0.01）. In odor response patterns of patients with exterior heat syndrome, the amplitudes and rising slopes of response curve A, B, D, E and H were significantly higher than those of patients with exterior cold syndrome （P〈0.05, P〈0.01）, and the amplitude of response curve G was significantly higher than that of patients with exterior cold syndrome （P〈0.01）. Discriminant analysis showed that the accuracy rate of oral breath identification of healthy students, patients with exterior cold syndrome and patients with exterior heat syndrome was 90.5%, 86.5% and 88.0% respectively, and the accuracy rate of all cases was 89.1%. Conclusion： The odors of oral breath of patients with exterior syndrome were significantly stronger than those of healthy people. The odors of patients with exterior heat syndrome were significantly stronger than those of patients with exterior cold syndrome. This medical electronic nose could distinguishodor characteristic of oral breath of patients with exterior syndrome sensitively and accurately; and it could also distinguish odor characteristic of exterior cold syndrome from exterior heat syndrome. The development of medical electronic nose could provide a kind of new means for the study on the objectification of TCM smelling examination.