甘草酸二铵磷脂复合物凝胶的体外透皮实验研究

Study on Skin Permeation of Diammonium Glycyrrhizinate Phospholipid Complex Gel

目的:考察甘草酸二铵磷脂复合物凝胶剂作为皮肤给药载体的渗透情况。方法:分别对凝胶材料、促渗剂和凝胶浓度进行筛选,采用改良的Franz扩散池,以离体人皮进行体外经皮渗透实验;以HPLC法测定接收夜和皮肤组织中的药物浓度。结果:以卡波姆为凝胶材料的处方渗透性优于泊洛沙姆和羟丙甲基纤维素,加入促渗剂不利于甘草酸二铵在皮肤中的转运,降低卡波姆凝胶浓度有利于甘草酸二铵的渗透。结论:以0.5%卡波姆为凝胶基质能增加甘草酸二铵在皮肤中的蓄积。

Objective ： To investigate the permeability of diammonium glycyrrhizinate phospholipid complex gel as skin drug delivery. Methods： Gel materials, penetration enhancers and gel concentrations were selected respectively. In vitro skin permeation experiments were carried out on modified Franz diffusion cells, using excised human skin. The concentra- tions of diammonium glycyrrhizinate in the receptor compartments and skin were determined by HPLC. Results ： The perme- ability of carbomer gel was better than poloxamer and hydroxypropyl methylcellulose;permeation enhancers did no good to cutaneous penetration of diammonium glycyrrhizinate, while reducing the concentration of carbomer can promote skin per- meation; Conclusion ：0.5 % carbomer gel could increase accumulation of diammonium glycyrrhizinate in the skin.